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Copper–zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma

Multiple myeloma (MM) is an incurable B-cell malignancy. The proteasome inhibitor bortezomib (BTZ) is a frontline MM drug; however, intrinsic or acquired resistance to BTZ remains a clinical hurdle. As BTZ induces oxidative stress in MM cells, we queried if altered redox homeostasis promotes BTZ res...

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Detalles Bibliográficos
Autores principales:	Salem, Kelley, McCormick, Michael L., Wendlandt, Erik, Zhan, Fenghuang, Goel, Apollina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309843/ https://www.ncbi.nlm.nih.gov/pubmed/25485927 http://dx.doi.org/10.1016/j.redox.2014.11.002

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