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Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile

Cyclooxygenase-2 (Cox-2) is rapidly expressed by various stimuli and plays a key role in conversion of free arachidonic acid to prostaglandins. We have previously identified 4-hydroxy-2-nonenal (HNE), a lipid peroxidation-derived electrophile, as the potent Cox-2 inducer in rat epithelial RL34 cells...

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Detalles Bibliográficos
Autores principales:	Kumagai, Takeshi, Usami, Hiroko, Matsukawa, Nao, Nakashima, Fumie, Chikazawa, Miho, Shibata, Takahiro, Noguchi, Noriko, Uchida, Koji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309852/ https://www.ncbi.nlm.nih.gov/pubmed/25506925 http://dx.doi.org/10.1016/j.redox.2014.11.011

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