Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells

High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS) production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-ind...

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Detalles Bibliográficos
Autores principales: Barlow, Jonathan, Hirschberg Jensen, Verena, Affourtit, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309862/
https://www.ncbi.nlm.nih.gov/pubmed/25482405
http://dx.doi.org/10.1016/j.redox.2014.11.009

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