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Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood

The offspring of depressed parents have been found to show elevated basal levels of the stress hormone cortisol. Whether heightened cortisol stress reactivity is also present in this group has yet to be clearly demonstrated. We tested whether postnatal maternal depression predicts subsequent increas...

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Autores principales: Barry, Tom J., Murray, Lynne, Fearon, R.M. Pasco, Moutsiana, Christina, Cooper, Peter, Goodyer, Ian M., Herbert, Joe, Halligan, Sarah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309884/
https://www.ncbi.nlm.nih.gov/pubmed/25544737
http://dx.doi.org/10.1016/j.psyneuen.2014.12.003
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author Barry, Tom J.
Murray, Lynne
Fearon, R.M. Pasco
Moutsiana, Christina
Cooper, Peter
Goodyer, Ian M.
Herbert, Joe
Halligan, Sarah L.
author_facet Barry, Tom J.
Murray, Lynne
Fearon, R.M. Pasco
Moutsiana, Christina
Cooper, Peter
Goodyer, Ian M.
Herbert, Joe
Halligan, Sarah L.
author_sort Barry, Tom J.
collection PubMed
description The offspring of depressed parents have been found to show elevated basal levels of the stress hormone cortisol. Whether heightened cortisol stress reactivity is also present in this group has yet to be clearly demonstrated. We tested whether postnatal maternal depression predicts subsequent increases in offspring biological sensitivity to social stress, as indexed by elevated cortisol reactivity. Participants (mean age 22.4-years) derived from a 22-year prospective longitudinal study of the offspring of mothers who had postnatal depression (PND group; n = 38) and a control group (n = 38). Salivary cortisol response to a social-evaluative threat (Trier Social Stress Test) was measured. Hierarchical linear modelling indicated that PND group offspring showed greater cortisol reactivity to the stress test than control group participants. Group differences were not explained by offspring depressive or anxiety symptoms, experiences of negative life events, elevated basal cortisol at age 13-years, subsequent exposure to maternal depression, or other key covariates. The findings indicate that the presence of early maternal depression can predict offspring biological sensitivity to social stress in adulthood, with potential implications for broader functioning.
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spelling pubmed-43098842015-02-14 Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood Barry, Tom J. Murray, Lynne Fearon, R.M. Pasco Moutsiana, Christina Cooper, Peter Goodyer, Ian M. Herbert, Joe Halligan, Sarah L. Psychoneuroendocrinology Article The offspring of depressed parents have been found to show elevated basal levels of the stress hormone cortisol. Whether heightened cortisol stress reactivity is also present in this group has yet to be clearly demonstrated. We tested whether postnatal maternal depression predicts subsequent increases in offspring biological sensitivity to social stress, as indexed by elevated cortisol reactivity. Participants (mean age 22.4-years) derived from a 22-year prospective longitudinal study of the offspring of mothers who had postnatal depression (PND group; n = 38) and a control group (n = 38). Salivary cortisol response to a social-evaluative threat (Trier Social Stress Test) was measured. Hierarchical linear modelling indicated that PND group offspring showed greater cortisol reactivity to the stress test than control group participants. Group differences were not explained by offspring depressive or anxiety symptoms, experiences of negative life events, elevated basal cortisol at age 13-years, subsequent exposure to maternal depression, or other key covariates. The findings indicate that the presence of early maternal depression can predict offspring biological sensitivity to social stress in adulthood, with potential implications for broader functioning. Pergamon Press 2015-02 /pmc/articles/PMC4309884/ /pubmed/25544737 http://dx.doi.org/10.1016/j.psyneuen.2014.12.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Barry, Tom J.
Murray, Lynne
Fearon, R.M. Pasco
Moutsiana, Christina
Cooper, Peter
Goodyer, Ian M.
Herbert, Joe
Halligan, Sarah L.
Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
title Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
title_full Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
title_fullStr Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
title_full_unstemmed Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
title_short Maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
title_sort maternal postnatal depression predicts altered offspring biological stress reactivity in adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309884/
https://www.ncbi.nlm.nih.gov/pubmed/25544737
http://dx.doi.org/10.1016/j.psyneuen.2014.12.003
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