Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions

Rapamycin, an inhibitor of mTOR activity, is a potent inducer of erythroid differentiation and fetal hemoglobin production in β-thalassemic patients. Mithramycin (MTH) was studied to see if this inducer of K562 differentiation also operates through inhibition of mTOR. We can conclude from the study...

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Detalles Bibliográficos
Autores principales: Finotti, Alessia, Bianchi, Nicoletta, Fabbri, Enrica, Borgatti, Monica, Breveglieri, Giulia, Gasparello, Jessica, Gambari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309890/
https://www.ncbi.nlm.nih.gov/pubmed/25478892
http://dx.doi.org/10.1016/j.phrs.2014.11.005

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