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Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus

BACKGROUND: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. METHODS: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient cli...

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Autores principales: Kahl, Kai G, Schweiger, Ulrich, Correll, Christoph, Müller, Conrad, Busch, Marie-Luise, Bauer, Michael, Schwarz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309892/
https://www.ncbi.nlm.nih.gov/pubmed/25642391
http://dx.doi.org/10.1002/brb3.306
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author Kahl, Kai G
Schweiger, Ulrich
Correll, Christoph
Müller, Conrad
Busch, Marie-Luise
Bauer, Michael
Schwarz, Peter
author_facet Kahl, Kai G
Schweiger, Ulrich
Correll, Christoph
Müller, Conrad
Busch, Marie-Luise
Bauer, Michael
Schwarz, Peter
author_sort Kahl, Kai G
collection PubMed
description BACKGROUND: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. METHODS: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. RESULTS: Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m(2)) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. CONCLUSIONS: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
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spelling pubmed-43098922015-01-30 Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus Kahl, Kai G Schweiger, Ulrich Correll, Christoph Müller, Conrad Busch, Marie-Luise Bauer, Michael Schwarz, Peter Brain Behav Original Research BACKGROUND: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. METHODS: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. RESULTS: Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m(2)) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. CONCLUSIONS: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM. Blackwell Publishing Ltd 2015-03 2015-01-21 /pmc/articles/PMC4309892/ /pubmed/25642391 http://dx.doi.org/10.1002/brb3.306 Text en © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Kahl, Kai G
Schweiger, Ulrich
Correll, Christoph
Müller, Conrad
Busch, Marie-Luise
Bauer, Michael
Schwarz, Peter
Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
title Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
title_full Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
title_fullStr Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
title_full_unstemmed Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
title_short Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
title_sort depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309892/
https://www.ncbi.nlm.nih.gov/pubmed/25642391
http://dx.doi.org/10.1002/brb3.306
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