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Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
BACKGROUND: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. METHODS: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient cli...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309892/ https://www.ncbi.nlm.nih.gov/pubmed/25642391 http://dx.doi.org/10.1002/brb3.306 |
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author | Kahl, Kai G Schweiger, Ulrich Correll, Christoph Müller, Conrad Busch, Marie-Luise Bauer, Michael Schwarz, Peter |
author_facet | Kahl, Kai G Schweiger, Ulrich Correll, Christoph Müller, Conrad Busch, Marie-Luise Bauer, Michael Schwarz, Peter |
author_sort | Kahl, Kai G |
collection | PubMed |
description | BACKGROUND: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. METHODS: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. RESULTS: Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m(2)) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. CONCLUSIONS: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM. |
format | Online Article Text |
id | pubmed-4309892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43098922015-01-30 Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus Kahl, Kai G Schweiger, Ulrich Correll, Christoph Müller, Conrad Busch, Marie-Luise Bauer, Michael Schwarz, Peter Brain Behav Original Research BACKGROUND: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. METHODS: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. RESULTS: Of 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m(2)) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. CONCLUSIONS: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM. Blackwell Publishing Ltd 2015-03 2015-01-21 /pmc/articles/PMC4309892/ /pubmed/25642391 http://dx.doi.org/10.1002/brb3.306 Text en © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Kahl, Kai G Schweiger, Ulrich Correll, Christoph Müller, Conrad Busch, Marie-Luise Bauer, Michael Schwarz, Peter Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
title | Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
title_full | Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
title_fullStr | Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
title_full_unstemmed | Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
title_short | Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
title_sort | depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309892/ https://www.ncbi.nlm.nih.gov/pubmed/25642391 http://dx.doi.org/10.1002/brb3.306 |
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