Cargando…

Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most important health problems in China. OBJECTIVES: This study analyzed expression of high-mobility group protein B1 (HMGB1) and inhibitor of apoptosis protein-2 (c-IAP2) proteins in HCC compared to paired para-tumor tissue samples to assess...

Descripción completa

Detalles Bibliográficos
Autores principales: Bi, Man Ru, Zhu, Li Ying, Yan, Bing Zhu, Chen, Li Yan, Wang, Fu Xiang, Ma, Ying Ji, Yang, Bao Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310020/
https://www.ncbi.nlm.nih.gov/pubmed/25685165
http://dx.doi.org/10.5812/hepatmon.23552
_version_ 1782354789372264448
author Bi, Man Ru
Zhu, Li Ying
Yan, Bing Zhu
Chen, Li Yan
Wang, Fu Xiang
Ma, Ying Ji
Yang, Bao Shan
author_facet Bi, Man Ru
Zhu, Li Ying
Yan, Bing Zhu
Chen, Li Yan
Wang, Fu Xiang
Ma, Ying Ji
Yang, Bao Shan
author_sort Bi, Man Ru
collection PubMed
description BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most important health problems in China. OBJECTIVES: This study analyzed expression of high-mobility group protein B1 (HMGB1) and inhibitor of apoptosis protein-2 (c-IAP2) proteins in HCC compared to paired para-tumor tissue samples to assess the association with HCC pathogenesis and progression. MATERIALS AND METHODS: Sixty-eight HCC and para-tumor tissue samples were collected for Western blot, qRT-PCR and immunohistochemical analyses of HMGB1 and c-IAP2. RESULTS: HMGB1 and c-IAP2 proteins were highly expressed in HCC tissue samples [85.3% (58/68) and 82.4% (56/68), respectively] compared to para-tumor tissue samples [32.3% and 27.9%, respectively]. Furthermore, expression of HMGB1 was significantly associated with enhanced c-IAP2 expression in HCC tissue samples (r = 0.878, P < 0.01). Expression of HMGB1 was associated with tumor multiplicity and size, alpha-fetoprotein (AFP) level and advanced TNM stage, while expression of c-IAP2 was associated with tumor size, AFP level and advanced TNM stage. CONCLUSIONS: Expression of HMGB1 and c-IAP2 proteins was associated with HCC development and progression, and the expression of HMGB1 and c-IAP2 proteins in HCC were significantly associated with each other. Additionally, these proteins may show promise as biomarkers to predict HCC progression.
format Online
Article
Text
id pubmed-4310020
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Kowsar
record_format MEDLINE/PubMed
spelling pubmed-43100202015-02-13 Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression Bi, Man Ru Zhu, Li Ying Yan, Bing Zhu Chen, Li Yan Wang, Fu Xiang Ma, Ying Ji Yang, Bao Shan Hepat Mon Research Article BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most important health problems in China. OBJECTIVES: This study analyzed expression of high-mobility group protein B1 (HMGB1) and inhibitor of apoptosis protein-2 (c-IAP2) proteins in HCC compared to paired para-tumor tissue samples to assess the association with HCC pathogenesis and progression. MATERIALS AND METHODS: Sixty-eight HCC and para-tumor tissue samples were collected for Western blot, qRT-PCR and immunohistochemical analyses of HMGB1 and c-IAP2. RESULTS: HMGB1 and c-IAP2 proteins were highly expressed in HCC tissue samples [85.3% (58/68) and 82.4% (56/68), respectively] compared to para-tumor tissue samples [32.3% and 27.9%, respectively]. Furthermore, expression of HMGB1 was significantly associated with enhanced c-IAP2 expression in HCC tissue samples (r = 0.878, P < 0.01). Expression of HMGB1 was associated with tumor multiplicity and size, alpha-fetoprotein (AFP) level and advanced TNM stage, while expression of c-IAP2 was associated with tumor size, AFP level and advanced TNM stage. CONCLUSIONS: Expression of HMGB1 and c-IAP2 proteins was associated with HCC development and progression, and the expression of HMGB1 and c-IAP2 proteins in HCC were significantly associated with each other. Additionally, these proteins may show promise as biomarkers to predict HCC progression. Kowsar 2014-12-15 /pmc/articles/PMC4310020/ /pubmed/25685165 http://dx.doi.org/10.5812/hepatmon.23552 Text en Copyright © 2014, Kowsar Corp. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Bi, Man Ru
Zhu, Li Ying
Yan, Bing Zhu
Chen, Li Yan
Wang, Fu Xiang
Ma, Ying Ji
Yang, Bao Shan
Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
title Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
title_full Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
title_fullStr Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
title_full_unstemmed Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
title_short Association of Upregulated HMGB1 and c-IAP2 Proteins With Hepatocellular Carcinoma Development and Progression
title_sort association of upregulated hmgb1 and c-iap2 proteins with hepatocellular carcinoma development and progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310020/
https://www.ncbi.nlm.nih.gov/pubmed/25685165
http://dx.doi.org/10.5812/hepatmon.23552
work_keys_str_mv AT bimanru associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression
AT zhuliying associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression
AT yanbingzhu associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression
AT chenliyan associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression
AT wangfuxiang associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression
AT mayingji associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression
AT yangbaoshan associationofupregulatedhmgb1andciap2proteinswithhepatocellularcarcinomadevelopmentandprogression