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Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage

BACKGROUND: In osteoarthritis (OA), the imbalance of chondrocytes’ anabolic and catabolic factors can induce cartilage destruction. Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that is capable of inducing chondrocytes and synovial cells to synthesize MMPs. The hypoxia-inducible f...

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Detalles Bibliográficos
Autores principales:	Sheu, Shiow-Yunn, Ho, Shin-Rong, Sun, Jui-Sheng, Chen, Ching-Yun, Ke, Cherng-Jyh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310028/ https://www.ncbi.nlm.nih.gov/pubmed/25617057 http://dx.doi.org/10.1186/s12906-015-0520-z

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