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Reduced T-cell repertoire restrictions in abatacept-treated rheumatoid arthritis patients

BACKGROUND: CD28(neg) T cells, which display functional characteristic of oligoclonally expanded cytotoxic memory T lymphocytes, are believed to be pathologically relevant in rheumatoid arthritis manifestation. The CD28 co-stimulation blockade by abatacept can prevent the generation of CD28(neg) T-c...

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Detalles Bibliográficos
Autores principales:	Imberti, Luisa, Scarsi, Mirko, Zanotti, Cinzia, Chiarini, Marco, Bertoli, Diego, Tincani, Angela, Airò, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310138/ https://www.ncbi.nlm.nih.gov/pubmed/25592982 http://dx.doi.org/10.1186/s12967-014-0363-2

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