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Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease

BACKGROUND: Celiac disease (CD) is a global health problem and its prevalence is underestimated, especially in Latin American populations. Our aim was to evaluate the clinical features, psychological factors, and health-related quality of life (QoL), before and after diagnosis, in a representative s...

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Autores principales: Ramírez-Cervantes, Karen Lizzete, Remes-Troche, José María, del Pilar Milke-García, María, Romero, Viridiana, Uscanga, Luis F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310198/
https://www.ncbi.nlm.nih.gov/pubmed/25608449
http://dx.doi.org/10.1186/s12876-015-0229-y
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author Ramírez-Cervantes, Karen Lizzete
Remes-Troche, José María
del Pilar Milke-García, María
Romero, Viridiana
Uscanga, Luis F
author_facet Ramírez-Cervantes, Karen Lizzete
Remes-Troche, José María
del Pilar Milke-García, María
Romero, Viridiana
Uscanga, Luis F
author_sort Ramírez-Cervantes, Karen Lizzete
collection PubMed
description BACKGROUND: Celiac disease (CD) is a global health problem and its prevalence is underestimated, especially in Latin American populations. Our aim was to evaluate the clinical features, psychological factors, and health-related quality of life (QoL), before and after diagnosis, in a representative sample of adult Mexican Mestizo patients presenting with CD. METHODS: A cross-sectional analysis was conducted on patients seen at two tertiary referral centers in Mexico. QoL before and after CD diagnosis was evaluated using the EuroQoL 5D, the Hospital Anxiety and Depression Scale (HADS), and the disease-specific Celiac Symptom Index (CSI) questionnaires. RESULTS: We included 80 patients (80% were women, with a mean age of 48.6 ± 14.1 years). The most common symptoms were diarrhea (86%), bloating (77.5%), and abdominal pain (71.3%). Mean symptom duration was 10.33 ± 6.3 years. Fifty-one patients (63.8%) had a previous diagnosis of irritable bowel syndrome (IBS) and 23 (28.8%) had one of functional dyspepsia. Questionnaire respondents rated their health status at 50% before diagnosis (0 = worst imaginable state, 100 = best imaginable state) and there was a significant improvement of 26% after diagnosis. Thirty-nine percent of the patients had a CSI score > 45 and they were the ones that had been previously diagnosed most often with IBS (p = 0.13) or dyspepsia (p = .036). CONCLUSIONS: At the time of diagnosis, Mexican Mestizo patients with CD had poor QoL. Long-standing symptoms and a previous diagnosis of functional disorders were associated with worse QoL. As in other populations, our results support the need for a detailed examination of cost-effective strategies for increasing CD awareness in clinical practice.
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spelling pubmed-43101982015-01-30 Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease Ramírez-Cervantes, Karen Lizzete Remes-Troche, José María del Pilar Milke-García, María Romero, Viridiana Uscanga, Luis F BMC Gastroenterol Research Article BACKGROUND: Celiac disease (CD) is a global health problem and its prevalence is underestimated, especially in Latin American populations. Our aim was to evaluate the clinical features, psychological factors, and health-related quality of life (QoL), before and after diagnosis, in a representative sample of adult Mexican Mestizo patients presenting with CD. METHODS: A cross-sectional analysis was conducted on patients seen at two tertiary referral centers in Mexico. QoL before and after CD diagnosis was evaluated using the EuroQoL 5D, the Hospital Anxiety and Depression Scale (HADS), and the disease-specific Celiac Symptom Index (CSI) questionnaires. RESULTS: We included 80 patients (80% were women, with a mean age of 48.6 ± 14.1 years). The most common symptoms were diarrhea (86%), bloating (77.5%), and abdominal pain (71.3%). Mean symptom duration was 10.33 ± 6.3 years. Fifty-one patients (63.8%) had a previous diagnosis of irritable bowel syndrome (IBS) and 23 (28.8%) had one of functional dyspepsia. Questionnaire respondents rated their health status at 50% before diagnosis (0 = worst imaginable state, 100 = best imaginable state) and there was a significant improvement of 26% after diagnosis. Thirty-nine percent of the patients had a CSI score > 45 and they were the ones that had been previously diagnosed most often with IBS (p = 0.13) or dyspepsia (p = .036). CONCLUSIONS: At the time of diagnosis, Mexican Mestizo patients with CD had poor QoL. Long-standing symptoms and a previous diagnosis of functional disorders were associated with worse QoL. As in other populations, our results support the need for a detailed examination of cost-effective strategies for increasing CD awareness in clinical practice. BioMed Central 2015-01-22 /pmc/articles/PMC4310198/ /pubmed/25608449 http://dx.doi.org/10.1186/s12876-015-0229-y Text en © Ramírez-Cervantes et al.; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ramírez-Cervantes, Karen Lizzete
Remes-Troche, José María
del Pilar Milke-García, María
Romero, Viridiana
Uscanga, Luis F
Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease
title Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease
title_full Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease
title_fullStr Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease
title_full_unstemmed Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease
title_short Characteristics and factors related to quality of life in Mexican Mestizo patients with celiac disease
title_sort characteristics and factors related to quality of life in mexican mestizo patients with celiac disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310198/
https://www.ncbi.nlm.nih.gov/pubmed/25608449
http://dx.doi.org/10.1186/s12876-015-0229-y
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