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Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence
Parkinson's disease (PD) is the world's second most common neurodegenerative disease and most common movement disorder. Characterised by a loss of dopaminergic neurons and the development of intraneuronal inclusions known as Lewy bodies, it has classically been thought of as a cell-autonom...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310229/ https://www.ncbi.nlm.nih.gov/pubmed/25653875 http://dx.doi.org/10.1155/2015/345285 |
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author | Chauhan, Aneesha Jeans, Alexander F. |
author_facet | Chauhan, Aneesha Jeans, Alexander F. |
author_sort | Chauhan, Aneesha |
collection | PubMed |
description | Parkinson's disease (PD) is the world's second most common neurodegenerative disease and most common movement disorder. Characterised by a loss of dopaminergic neurons and the development of intraneuronal inclusions known as Lewy bodies, it has classically been thought of as a cell-autonomous disease. However, in 2008, two groups reported the startling observation of Lewy bodies within embryonic neuronal grafts transplanted into PD patients little more than a decade previously, suggesting that PD pathology can be propagated to neighbouring cells and calling basic assumptions of our understanding of the disease into question. Subsequent research has largely served to confirm this interpretation, pointing towards a prion-like intercellular transfer of misfolded α-synuclein, the main component of Lewy bodies, as central to PD. This shift in thinking offers a revolutionary approach to PD treatment, potentially enabling a transition from purely symptomatic therapy to direct targeting of the pathology that drives disease progression. In this short review, we appraise current experimental support for PD as a prion-like disease, whilst highlighting areas of controversy or inconsistency which must be resolved. We also offer a brief discussion of the therapeutic implications of these discoveries. |
format | Online Article Text |
id | pubmed-4310229 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43102292015-02-04 Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence Chauhan, Aneesha Jeans, Alexander F. Neurol Res Int Review Article Parkinson's disease (PD) is the world's second most common neurodegenerative disease and most common movement disorder. Characterised by a loss of dopaminergic neurons and the development of intraneuronal inclusions known as Lewy bodies, it has classically been thought of as a cell-autonomous disease. However, in 2008, two groups reported the startling observation of Lewy bodies within embryonic neuronal grafts transplanted into PD patients little more than a decade previously, suggesting that PD pathology can be propagated to neighbouring cells and calling basic assumptions of our understanding of the disease into question. Subsequent research has largely served to confirm this interpretation, pointing towards a prion-like intercellular transfer of misfolded α-synuclein, the main component of Lewy bodies, as central to PD. This shift in thinking offers a revolutionary approach to PD treatment, potentially enabling a transition from purely symptomatic therapy to direct targeting of the pathology that drives disease progression. In this short review, we appraise current experimental support for PD as a prion-like disease, whilst highlighting areas of controversy or inconsistency which must be resolved. We also offer a brief discussion of the therapeutic implications of these discoveries. Hindawi Publishing Corporation 2015 2015-01-13 /pmc/articles/PMC4310229/ /pubmed/25653875 http://dx.doi.org/10.1155/2015/345285 Text en Copyright © 2015 A. Chauhan and A. F. Jeans. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chauhan, Aneesha Jeans, Alexander F. Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence |
title | Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence |
title_full | Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence |
title_fullStr | Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence |
title_full_unstemmed | Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence |
title_short | Is Parkinson's Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence |
title_sort | is parkinson's disease truly a prion-like disorder? an appraisal of current evidence |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310229/ https://www.ncbi.nlm.nih.gov/pubmed/25653875 http://dx.doi.org/10.1155/2015/345285 |
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