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Structure of an Rrp6-RNA exosome complex bound to polyA RNA

The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the distributive or processive 3′ to 5′ exoribonuclease activities of Rrp6 or Rrp44, respectively. The non-catalytic nine-subunit exosome core (Exo9) features a prominent central channel. While RNA can pass through the...

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Detalles Bibliográficos
Autores principales: Wasmuth, Elizabeth V., Januszyk, Kurt, Lima, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310248/
https://www.ncbi.nlm.nih.gov/pubmed/25043052
http://dx.doi.org/10.1038/nature13406