Investigation of gene effects and epistatic interactions between Akt1 and neuregulin 1 in the regulation of behavioral phenotypes and social functions in genetic mouse models of schizophrenia

Accumulating evidence from human genetic studies has suggested several functional candidate genes that might contribute to susceptibility to schizophrenia, including AKT1 and neuregulin 1 (NRG1). Recent findings also revealed that NRG1 stimulates the PI3-kinase/AKT signaling pathway, which might be...

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Detalles Bibliográficos
Autores principales: Huang, Ching-Hsun, Pei, Ju-Chun, Luo, Da-Zhong, Chen, Ching, Chen, Yi-Wen, Lai, Wen-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310298/
https://www.ncbi.nlm.nih.gov/pubmed/25688191
http://dx.doi.org/10.3389/fnbeh.2014.00455

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