Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis

We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We d...

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Autores principales: Deguchi, Hajime, Aoyama, Riho, Takahashi, Hideaki, Isobe, Yoshinari, Tsutsumi, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310308/
https://www.ncbi.nlm.nih.gov/pubmed/25648414
http://dx.doi.org/10.1155/2015/898262
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author Deguchi, Hajime
Aoyama, Riho
Takahashi, Hideaki
Isobe, Yoshinari
Tsutsumi, Yutaka
author_facet Deguchi, Hajime
Aoyama, Riho
Takahashi, Hideaki
Isobe, Yoshinari
Tsutsumi, Yutaka
author_sort Deguchi, Hajime
collection PubMed
description We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We discuss that the removal of horny layer lipids by surface-active detergents accelerates the transepidermal water loss and disturbs the barrier function of the epidermis and thus is intimately involved in the pathogenesis of atopic dermatitis.
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spelling pubmed-43103082015-02-03 Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis Deguchi, Hajime Aoyama, Riho Takahashi, Hideaki Isobe, Yoshinari Tsutsumi, Yutaka Case Rep Dermatol Med Case Report We report herein two cases of intractable atopic dermatitis successfully treated by simply avoiding the contact with surface-active detergents in the daily life and living. The detergents were closely related to the exacerbation and remission of the disease. Steroid ointment was no longer used. We discuss that the removal of horny layer lipids by surface-active detergents accelerates the transepidermal water loss and disturbs the barrier function of the epidermis and thus is intimately involved in the pathogenesis of atopic dermatitis. Hindawi Publishing Corporation 2015 2015-01-15 /pmc/articles/PMC4310308/ /pubmed/25648414 http://dx.doi.org/10.1155/2015/898262 Text en Copyright © 2015 Hajime Deguchi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Deguchi, Hajime
Aoyama, Riho
Takahashi, Hideaki
Isobe, Yoshinari
Tsutsumi, Yutaka
Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
title Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
title_full Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
title_fullStr Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
title_full_unstemmed Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
title_short Harmful Effects of Synthetic Surface-Active Detergents against Atopic Dermatitis
title_sort harmful effects of synthetic surface-active detergents against atopic dermatitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310308/
https://www.ncbi.nlm.nih.gov/pubmed/25648414
http://dx.doi.org/10.1155/2015/898262
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AT takahashihideaki harmfuleffectsofsyntheticsurfaceactivedetergentsagainstatopicdermatitis
AT isobeyoshinari harmfuleffectsofsyntheticsurfaceactivedetergentsagainstatopicdermatitis
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