Transgenic Knockdown of Cardiac Sodium/Glucose Cotransporter 1 (SGLT1) Attenuates PRKAG2 Cardiomyopathy, Whereas Transgenic Overexpression of Cardiac SGLT1 Causes Pathologic Hypertrophy and Dysfunction in Mice

BACKGROUND: The expression of a novel cardiac glucose transporter, SGLT1, is increased in glycogen storage cardiomyopathy secondary to mutations in PRKAG2. We sought to determine the role of SGLT1 in the pathogenesis of PRKAG2 cardiomyopathy and its role in cardiac structure and function. METHODS AN...

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Detalles Bibliográficos
Autores principales: Ramratnam, Mohun, Sharma, Ravi K., D'Auria, Stephen, Lee, So Jung, Wang, David, Huang, Xue Yin N., Ahmad, Ferhaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310371/
https://www.ncbi.nlm.nih.gov/pubmed/25092788
http://dx.doi.org/10.1161/JAHA.114.000899

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