Reducing Endoglin Activity Limits Calcineurin and TRPC‐6 Expression and Improves Survival in a Mouse Model of Right Ventricular Pressure Overload

BACKGROUND: Right ventricular (RV) failure is a major cause of mortality worldwide and is often a consequence of RV pressure overload (RVPO). Endoglin is a coreceptor for the profibrogenic cytokine, transforming growth factor beta 1 (TGF‐β1). TGF‐β1 signaling by the canonical transient receptor prot...

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Detalles Bibliográficos
Autores principales: Kapur, Navin K., Qiao, Xiaoying, Paruchuri, Vikram, Mackey, Emily E., Daly, Gerard H., Ughreja, Keshan, Morine, Kevin J., Levine, Jonathan, Aronovitz, Mark J., Hill, Nicholas S., Jaffe, Iris Z., Letarte, Michelle, Karas, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310384/
https://www.ncbi.nlm.nih.gov/pubmed/25015075
http://dx.doi.org/10.1161/JAHA.114.000965

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