Cardioprotection by Controlling Hyperamylinemia in a “Humanized” Diabetic Rat Model

BACKGROUND: Chronic hypersecretion of the pancreatic hormone amylin is common in humans with obesity or prediabetic insulin resistance and induces amylin aggregation and proteotoxicity in the pancreas. We recently showed that hyperamylinemia also affects the cardiovascular system. Here, we investiga...

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Detalles Bibliográficos
Autores principales: Despa, Sanda, Sharma, Savita, Harris, Todd R., Dong, Hua, Li, Ning, Chiamvimonvat, Nipavan, Taegtmeyer, Heinrich, Margulies, Kenneth B., Hammock, Bruce D., Despa, Florin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310392/
https://www.ncbi.nlm.nih.gov/pubmed/25146704
http://dx.doi.org/10.1161/JAHA.114.001015

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