A Low‐Frequency Variant in MAPK14 Provides Mechanistic Evidence of a Link With Myeloperoxidase: A Prognostic Cardiovascular Risk Marker

BACKGROUND: Genetics can be used to predict drug effects and generate hypotheses around alternative indications. To support Losmapimod, a p38 mitogen‐activated protein kinase inhibitor in development for acute coronary syndrome, we characterized gene variation in MAPK11/14 genes by exome sequencing...

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Detalles Bibliográficos
Autores principales: Waterworth, Dawn M., Li, Li, Scott, Robert, Warren, Liling, Gillson, Christopher, Aponte, Jennifer, Sarov‐Blat, Lea, Sprecher, Dennis, Dupuis, Josée, Reiner, Alex, Psaty, Bruce M., Tracy, Russell P., Lin, Honghuang, McPherson, Ruth, Chissoe, Stephanie, Wareham, Nick, Ehm, Margaret G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310399/
https://www.ncbi.nlm.nih.gov/pubmed/25164947
http://dx.doi.org/10.1161/JAHA.114.001074

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