Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein

Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, K(i) = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, K(i) = 49.0 ± 4.9 nM), were radiolabeled as potential PET imaging agents by respectively introducing (11)C and (18)F. The syntheses of [(11)C]2a and [(18)F]2b...

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Detalles Bibliográficos
Autores principales: Zhang, Xiang, Jin, Hongjun, Padakanti, Prashanth K., Li, Junfeng, Yang, Hao, Fan, Jinda, Mach, Robert H., Kotzbauer, Paul, Tu, Zhude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310556/
https://www.ncbi.nlm.nih.gov/pubmed/25642331
http://dx.doi.org/10.3390/app4010066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310556/
https://www.ncbi.nlm.nih.gov/pubmed/25642331
http://dx.doi.org/10.3390/app4010066

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