The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

DNA strand-breaks (SBs) with non-ligatable ends are generated by ionizing radiation, oxidative stress, various chemotherapeutic agents, and also as base excision repair (BER) intermediates. Several neurological diseases have already been identified as being due to a deficiency in DNA end-processing...

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Detalles Bibliográficos
Autores principales: Chatterjee, Arpita, Saha, Saikat, Chakraborty, Anirban, Silva-Fernandes, Anabela, Mandal, Santi M., Neves-Carvalho, Andreia, Liu, Yongping, Pandita, Raj K., Hegde, Muralidhar L., Hegde, Pavana M., Boldogh, Istvan, Ashizawa, Tetsuo, Koeppen, Arnulf H., Pandita, Tej K., Maciel, Patricia, Sarkar, Partha S., Hazra, Tapas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310589/
https://www.ncbi.nlm.nih.gov/pubmed/25633985
http://dx.doi.org/10.1371/journal.pgen.1004749

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