A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

BACKGROUND: Conventional wisdom holds that, owing to the dominance of features such as chromatin level control, the expression of a gene cannot be readily predicted from knowledge of promoter architecture. This is reflected, for example, in a weak or absent correlation between promoter divergence an...

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Detalles Bibliográficos
Autores principales: Hurst, Laurence D, Sachenkova, Oxana, Daub, Carsten, Forrest, Alistair RR, Huminiecki, Lukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310617/
https://www.ncbi.nlm.nih.gov/pubmed/25079787
http://dx.doi.org/10.1186/s13059-014-0413-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310617/
https://www.ncbi.nlm.nih.gov/pubmed/25079787
http://dx.doi.org/10.1186/s13059-014-0413-3

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