Experimental Strategies for Functional Annotation and Metabolism Discovery: Targeted Screening of Solute Binding Proteins and Unbiased Panning of Metabolomes

[Image: see text] The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic pathway, thereby constraining the regions of chemical space...

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Detalles Bibliográficos
Autores principales: Vetting, Matthew W., Al-Obaidi, Nawar, Zhao, Suwen, San Francisco, Brian, Kim, Jungwook, Wichelecki, Daniel J., Bouvier, Jason T., Solbiati, Jose O., Vu, Hoan, Zhang, Xinshuai, Rodionov, Dmitry A., Love, James D., Hillerich, Brandan S., Seidel, Ronald D., Quinn, Ronald J., Osterman, Andrei L., Cronan, John E., Jacobson, Matthew P., Gerlt, John A., Almo, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310620/
https://www.ncbi.nlm.nih.gov/pubmed/25540822
http://dx.doi.org/10.1021/bi501388y

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