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Oxidation of p53 through DNA Charge Transport Involves a Network of Disulfides within the DNA-Binding Domain

[Image: see text] Transcription factor p53 plays a critical role in the cellular response to stress stimuli. We have seen that p53 dissociates selectively from various promoter sites as a result of oxidation at long-range through DNA-mediated charge transport (CT). Here, we examine this chemical oxi...

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Detalles Bibliográficos
Autores principales:	Schaefer, Kathryn N., Geil, Wendy M., Sweredoski, Michael J., Moradian, Annie, Hess, Sonja, Barton, Jacqueline K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310631/ https://www.ncbi.nlm.nih.gov/pubmed/25584637 http://dx.doi.org/10.1021/bi501424v

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