Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

[Image: see text] To explore the feasibility of developing ligands targeted to the atypical C1 domains of protein kinase C ζ and ι, we have prepared diacylglycerol lactones substituted with hydrophilic groups on their side chains, which potentially could interact with the arginine residues that dist...

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Detalles Bibliográficos
Autores principales: Pu, Yongmei, Kang, Ji-Hye, Sigano, Dina M., Peach, Megan L., Lewin, Nancy E., Marquez, Victor E., Blumberg, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310642/
https://www.ncbi.nlm.nih.gov/pubmed/24684293
http://dx.doi.org/10.1021/jm500165n

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