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Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons

Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that withi...

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Autores principales: Kirby, Elizabeth D., Friedman, Aaron R., Covarrubias, David, Ying, Carl, Sun, Wayne G., Goosens, Ki A., Sapolsky, Robert M., Kaufer, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310700/
https://www.ncbi.nlm.nih.gov/pubmed/21670733
http://dx.doi.org/10.1038/mp.2011.71
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author Kirby, Elizabeth D.
Friedman, Aaron R.
Covarrubias, David
Ying, Carl
Sun, Wayne G.
Goosens, Ki A.
Sapolsky, Robert M.
Kaufer, Daniela
author_facet Kirby, Elizabeth D.
Friedman, Aaron R.
Covarrubias, David
Ying, Carl
Sun, Wayne G.
Goosens, Ki A.
Sapolsky, Robert M.
Kaufer, Daniela
author_sort Kirby, Elizabeth D.
collection PubMed
description Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that within the adult hippocampus, newborn neurons may contribute to support of emotional memory, and that regulation of hippocampal neurogenesis is implicated in depressive disorders. How emotional information impacts newborn neurons in adults is not clear. Given the role of the BLA in hippocampus-dependent emotional memory, we investigated whether hippocampal neurogenesis was sensitive to emotional stimuli from the BLA. We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus of the amygdala do not. Similarly, we show that reducing BLA activity through viral vector-mediated overexpression of an outwardly rectifying potassium channel suppresses neurogenesis. We also show that BLA lesions prevent selective activation of immature newborn neurons in response to a fear conditioning task. These results demonstrate that BLA activity regulates adult hippocampal neurogenesis and the fear context-specific activation of newborn neurons. Together, these findings denote functional implications for proliferation and recruitment of new neurons into emotional memory circuits.
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spelling pubmed-43107002015-01-29 Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons Kirby, Elizabeth D. Friedman, Aaron R. Covarrubias, David Ying, Carl Sun, Wayne G. Goosens, Ki A. Sapolsky, Robert M. Kaufer, Daniela Mol Psychiatry Article Impaired regulation of emotional memory is a feature of several affective disorders, including depression, anxiety and post-traumatic stress disorder. Such regulation occurs, in part, by interactions between the hippocampus and the basolateral amygdala (BLA). Recent studies have indicated that within the adult hippocampus, newborn neurons may contribute to support of emotional memory, and that regulation of hippocampal neurogenesis is implicated in depressive disorders. How emotional information impacts newborn neurons in adults is not clear. Given the role of the BLA in hippocampus-dependent emotional memory, we investigated whether hippocampal neurogenesis was sensitive to emotional stimuli from the BLA. We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus of the amygdala do not. Similarly, we show that reducing BLA activity through viral vector-mediated overexpression of an outwardly rectifying potassium channel suppresses neurogenesis. We also show that BLA lesions prevent selective activation of immature newborn neurons in response to a fear conditioning task. These results demonstrate that BLA activity regulates adult hippocampal neurogenesis and the fear context-specific activation of newborn neurons. Together, these findings denote functional implications for proliferation and recruitment of new neurons into emotional memory circuits. 2011-06-14 2012-05 /pmc/articles/PMC4310700/ /pubmed/21670733 http://dx.doi.org/10.1038/mp.2011.71 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kirby, Elizabeth D.
Friedman, Aaron R.
Covarrubias, David
Ying, Carl
Sun, Wayne G.
Goosens, Ki A.
Sapolsky, Robert M.
Kaufer, Daniela
Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_full Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_fullStr Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_full_unstemmed Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_short Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
title_sort basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310700/
https://www.ncbi.nlm.nih.gov/pubmed/21670733
http://dx.doi.org/10.1038/mp.2011.71
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