TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency

Glycine-N-methyltransferase (GNMT) is essential to preserve liver homeostasis. Thus, cirrhotic patients show low expression of GNMT that is absent in HCC samples. Accordingly, GNMT deficiency in mice leads to steatohepatitis, fibrosis, cirrhosis and HCC. Lack of GNMT triggers NK cell activation in G...

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Detalles Bibliográficos
Autores principales: Fernández-Álvarez, Sara, Juan, Virginia Gutiérrez-de, Zubiete-Franco, Imanol, Barbier-Torres, Lucia, Lahoz, Agustín, Parés, Albert, Luka, Zigmund, Wagner, Conrad, Lu, Shelly C., Mato, José M., Martínez-Chantar, María Luz, Beraza, Naiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310762/
https://www.ncbi.nlm.nih.gov/pubmed/25531568
http://dx.doi.org/10.1038/labinvest.2014.151

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