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Associations among Pericolonic Fat, Visceral Fat, and Colorectal Polyps on CT Colonography

OBJECTIVE: To determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC). METHODS: 1169 patients who underwent CTC and same day optical colonoscopy were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Visceral adipose tissue vol...

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Detalles Bibliográficos
Autores principales: Liu, Jiamin, Pattanaik, Sanket, Yao, Jianhua, Dwyer, Andrew J., Pickhardt, Perry J., Choi, J. Richard, Summers, Ronald M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310815/
https://www.ncbi.nlm.nih.gov/pubmed/25558027
http://dx.doi.org/10.1002/oby.20987
Descripción
Sumario:OBJECTIVE: To determine the association between pericolonic fat and colorectal polyps using CT colonography (CTC). METHODS: 1169 patients who underwent CTC and same day optical colonoscopy were assessed. Pericolonic fat was measured on CTC in a band surrounding the colon. Visceral adipose tissue volume was measured at the L2-L3 levels. Student t-tests, odds ratio, logistic regression, binomial statistics and weighted-kappa were performed to ascertain associations with the incidence of colorectal polyps. RESULTS: Pericolonic fat volume fractions (PFVF) were 61.5±11.0% versus 58.1±11.5%, 61.6 ±11.1% versus 58.7±11.5%, and 62.4±10.6% versus 58.8±11.5% for patients with and without any polyps, adenomatous polyps, and hyperplastic polyps, respectively (p<0.0001). Similar trends were observed when examining visceral fat volume fractions (VFVF). When patients were ordered by quintiles of PFVF or VFVF, there were 2.49, 2.19 and 2.39-fold increases in odds ratio for the presence of any polyp, adenomatous polyps, or hyperplastic polyps from the first to the fifth quintile for PFVF, and 1.92, 2.00 and 1.71-fold increases in odds ratio for VFVF. Polyps tended to occur more commonly in parts of the colon that had more PFVF than the spatially-adjusted average for patients in the highest quintile of VFVF. CONCLUSION: Pericolonic fat accumulations, like visceral fat, are correlated with an increased risk of adenomatous and hyperplastic polyps.