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Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter

Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress, and health behaviors. Cross-sectionally, highly stressed post-menopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere l...

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Autores principales: Puterman, Eli, Lin, Jue, Krauss, Jeffrey, Blackburn, Elizabeth H., Epel, Elissa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310821/
https://www.ncbi.nlm.nih.gov/pubmed/25070535
http://dx.doi.org/10.1038/mp.2014.70
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author Puterman, Eli
Lin, Jue
Krauss, Jeffrey
Blackburn, Elizabeth H.
Epel, Elissa S.
author_facet Puterman, Eli
Lin, Jue
Krauss, Jeffrey
Blackburn, Elizabeth H.
Epel, Elissa S.
author_sort Puterman, Eli
collection PubMed
description Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress, and health behaviors. Cross-sectionally, highly stressed post-menopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors. Here we followed healthy women over one year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect. In 239 post-menopausal, non-smoking, disease-free women, accumulation of major life stressors across a one-year period predicted telomere attrition over the same period - for every major life stressor that occurred during the year, there was a significantly greater decline in telomere length over the year of 35 base pairs (p < .05). Yet, these effects were moderated by health behaviors (interaction B = 0.19, p = .04). Women who maintained relatively higher levels of health behaviors (one standard deviation above the mean) appeared to be protected when exposed to stress. This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects. This is the first study to identify predictors of telomere length change over the short period of a year.
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spelling pubmed-43108212015-10-01 Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter Puterman, Eli Lin, Jue Krauss, Jeffrey Blackburn, Elizabeth H. Epel, Elissa S. Mol Psychiatry Article Telomere length, a reliable predictor of disease pathogenesis, can be affected by genetics, chronic stress, and health behaviors. Cross-sectionally, highly stressed post-menopausal women have shorter telomeres, but only if they are inactive. However, no studies have prospectively examined telomere length change over a short period, and if rate of attrition is affected by naturalistic factors such as stress and engagement in healthy behaviors. Here we followed healthy women over one year to test if major stressors that occurred over the year predicted telomere shortening, and whether engaging in healthy behaviors during this period mitigates this effect. In 239 post-menopausal, non-smoking, disease-free women, accumulation of major life stressors across a one-year period predicted telomere attrition over the same period - for every major life stressor that occurred during the year, there was a significantly greater decline in telomere length over the year of 35 base pairs (p < .05). Yet, these effects were moderated by health behaviors (interaction B = 0.19, p = .04). Women who maintained relatively higher levels of health behaviors (one standard deviation above the mean) appeared to be protected when exposed to stress. This finding has implications for understanding malleability of telomere length, as well as expectations for possible intervention effects. This is the first study to identify predictors of telomere length change over the short period of a year. 2014-07-29 2015-04 /pmc/articles/PMC4310821/ /pubmed/25070535 http://dx.doi.org/10.1038/mp.2014.70 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Puterman, Eli
Lin, Jue
Krauss, Jeffrey
Blackburn, Elizabeth H.
Epel, Elissa S.
Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter
title Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter
title_full Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter
title_fullStr Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter
title_full_unstemmed Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter
title_short Determinants of telomere attrition over one year in healthy older women: Stress and health behaviors matter
title_sort determinants of telomere attrition over one year in healthy older women: stress and health behaviors matter
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310821/
https://www.ncbi.nlm.nih.gov/pubmed/25070535
http://dx.doi.org/10.1038/mp.2014.70
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