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Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study

BACKGROUND: The association of aspirin use and nonsteroid anti-inflammatory drug (NSAID) use with amyotrophic lateral sclerosis (ALS) risk is unclear. This study determined whether use of any individual compound is associated with ALS risk by conducting a total population-based case-control study in...

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Autores principales: Tsai, Ching-Piao, Lin, Feng-Cheng, Lee, Johnny Kuang-Wu, Lee, Charles Tzu-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310879/
https://www.ncbi.nlm.nih.gov/pubmed/25721071
http://dx.doi.org/10.2188/jea.JE20140070
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author Tsai, Ching-Piao
Lin, Feng-Cheng
Lee, Johnny Kuang-Wu
Lee, Charles Tzu-Chi
author_facet Tsai, Ching-Piao
Lin, Feng-Cheng
Lee, Johnny Kuang-Wu
Lee, Charles Tzu-Chi
author_sort Tsai, Ching-Piao
collection PubMed
description BACKGROUND: The association of aspirin use and nonsteroid anti-inflammatory drug (NSAID) use with amyotrophic lateral sclerosis (ALS) risk is unclear. This study determined whether use of any individual compound is associated with ALS risk by conducting a total population-based case-control study in Taiwan. METHODS: A total of 729 patients with newly diagnosed ALS who had a severely disabling disease certificate between January 1, 2002, and December 1, 2008, comprised the case group. These cases were compared with 7290 sex-, age-, residence-, and insurance premium-matched controls. Drug use by each Anatomical Therapeutic Chemical code was analyzed using conditional logistic regression models. False discovery rate (FDR)-adjusted P values were reported in order to avoid inflating false positives. RESULTS: Of the 1336 compounds, only the 266 with use cases exceeding 30 in our database were included in the screening analysis. Without controlling for steroid use, the analysis failed to reveal any compound that was inversely associated with ALS risk according to FDR criteria. After controlling for steroid use, we found use of the following compounds to be associated with ALS risk: aspirin, diphenhydramine (one of the antihistamines), and mefenamic acid (one of the NSAIDs). A multivariate analysis revealed that aspirin was independently inversely associated with ALS risk after controlling for diphenhydramine, mefenamic acid, and steroid use. The inverse association between aspirin and ALS was present predominately in patients older than 55 years. CONCLUSIONS: The results of this study suggested that aspirin use might reduce the risk of ALS, and the benefit might be more prominent for older people.
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spelling pubmed-43108792015-02-09 Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study Tsai, Ching-Piao Lin, Feng-Cheng Lee, Johnny Kuang-Wu Lee, Charles Tzu-Chi J Epidemiol Original Article BACKGROUND: The association of aspirin use and nonsteroid anti-inflammatory drug (NSAID) use with amyotrophic lateral sclerosis (ALS) risk is unclear. This study determined whether use of any individual compound is associated with ALS risk by conducting a total population-based case-control study in Taiwan. METHODS: A total of 729 patients with newly diagnosed ALS who had a severely disabling disease certificate between January 1, 2002, and December 1, 2008, comprised the case group. These cases were compared with 7290 sex-, age-, residence-, and insurance premium-matched controls. Drug use by each Anatomical Therapeutic Chemical code was analyzed using conditional logistic regression models. False discovery rate (FDR)-adjusted P values were reported in order to avoid inflating false positives. RESULTS: Of the 1336 compounds, only the 266 with use cases exceeding 30 in our database were included in the screening analysis. Without controlling for steroid use, the analysis failed to reveal any compound that was inversely associated with ALS risk according to FDR criteria. After controlling for steroid use, we found use of the following compounds to be associated with ALS risk: aspirin, diphenhydramine (one of the antihistamines), and mefenamic acid (one of the NSAIDs). A multivariate analysis revealed that aspirin was independently inversely associated with ALS risk after controlling for diphenhydramine, mefenamic acid, and steroid use. The inverse association between aspirin and ALS was present predominately in patients older than 55 years. CONCLUSIONS: The results of this study suggested that aspirin use might reduce the risk of ALS, and the benefit might be more prominent for older people. Japan Epidemiological Association 2015-02-05 /pmc/articles/PMC4310879/ /pubmed/25721071 http://dx.doi.org/10.2188/jea.JE20140070 Text en © 2014 Ching-Piao Tsai et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Tsai, Ching-Piao
Lin, Feng-Cheng
Lee, Johnny Kuang-Wu
Lee, Charles Tzu-Chi
Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study
title Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study
title_full Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study
title_fullStr Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study
title_full_unstemmed Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study
title_short Aspirin Use Associated With Amyotrophic Lateral Sclerosis: a Total Population-Based Case-Control Study
title_sort aspirin use associated with amyotrophic lateral sclerosis: a total population-based case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310879/
https://www.ncbi.nlm.nih.gov/pubmed/25721071
http://dx.doi.org/10.2188/jea.JE20140070
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