Cargando…

Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()

BACKGROUND AND PURPOSE: Functional magnetic resonance imaging (fMRI) is a non-invasive pre-surgical tool used to assess localization and lateralization of language function in brain tumor and vascular lesion patients in order to guide neurosurgeons as they devise a surgical approach to treat these l...

Descripción completa

Detalles Bibliográficos
Autores principales: Nadkarni, Tanvi N., Andreoli, Matthew J., Nair, Veena A., Yin, Peng, Young, Brittany M., Kundu, Bornali, Pankratz, Joshua, Radtke, Andrew, Holdsworth, Ryan, Kuo, John S., Field, Aaron S., Baskaya, Mustafa K., Moritz, Chad H., Meyerand, M. Elizabeth, Prabhakaran, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310930/
https://www.ncbi.nlm.nih.gov/pubmed/25685705
http://dx.doi.org/10.1016/j.nicl.2014.12.014
_version_ 1782354931424952320
author Nadkarni, Tanvi N.
Andreoli, Matthew J.
Nair, Veena A.
Yin, Peng
Young, Brittany M.
Kundu, Bornali
Pankratz, Joshua
Radtke, Andrew
Holdsworth, Ryan
Kuo, John S.
Field, Aaron S.
Baskaya, Mustafa K.
Moritz, Chad H.
Meyerand, M. Elizabeth
Prabhakaran, Vivek
author_facet Nadkarni, Tanvi N.
Andreoli, Matthew J.
Nair, Veena A.
Yin, Peng
Young, Brittany M.
Kundu, Bornali
Pankratz, Joshua
Radtke, Andrew
Holdsworth, Ryan
Kuo, John S.
Field, Aaron S.
Baskaya, Mustafa K.
Moritz, Chad H.
Meyerand, M. Elizabeth
Prabhakaran, Vivek
author_sort Nadkarni, Tanvi N.
collection PubMed
description BACKGROUND AND PURPOSE: Functional magnetic resonance imaging (fMRI) is a non-invasive pre-surgical tool used to assess localization and lateralization of language function in brain tumor and vascular lesion patients in order to guide neurosurgeons as they devise a surgical approach to treat these lesions. We investigated the effect of varying the statistical thresholds as well as the type of language tasks on functional activation patterns and language lateralization. We hypothesized that language lateralization indices (LIs) would be threshold- and task-dependent. MATERIALS AND METHODS: Imaging data were collected from brain tumor patients (n = 67, average age 48 years) and vascular lesion patients (n = 25, average age 43 years) who received pre-operative fMRI scanning. Both patient groups performed expressive (antonym and/or letter-word generation) and receptive (tumor patients performed text-reading; vascular lesion patients performed text-listening) language tasks. A control group (n = 25, average age 45 years) performed the letter-word generation task. RESULTS: Brain tumor patients showed left-lateralization during the antonym-word generation and text-reading tasks at high threshold values and bilateral activation during the letter-word generation task, irrespective of the threshold values. Vascular lesion patients showed left-lateralization during the antonym and letter-word generation, and text-listening tasks at high threshold values. CONCLUSION: Our results suggest that the type of task and the applied statistical threshold influence LI and that the threshold effects on LI may be task-specific. Thus identifying critical functional regions and computing LIs should be conducted on an individual subject basis, using a continuum of threshold values with different tasks to provide the most accurate information for surgical planning to minimize post-operative language deficits.
format Online
Article
Text
id pubmed-4310930
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-43109302015-02-14 Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()() Nadkarni, Tanvi N. Andreoli, Matthew J. Nair, Veena A. Yin, Peng Young, Brittany M. Kundu, Bornali Pankratz, Joshua Radtke, Andrew Holdsworth, Ryan Kuo, John S. Field, Aaron S. Baskaya, Mustafa K. Moritz, Chad H. Meyerand, M. Elizabeth Prabhakaran, Vivek Neuroimage Clin Regular Article BACKGROUND AND PURPOSE: Functional magnetic resonance imaging (fMRI) is a non-invasive pre-surgical tool used to assess localization and lateralization of language function in brain tumor and vascular lesion patients in order to guide neurosurgeons as they devise a surgical approach to treat these lesions. We investigated the effect of varying the statistical thresholds as well as the type of language tasks on functional activation patterns and language lateralization. We hypothesized that language lateralization indices (LIs) would be threshold- and task-dependent. MATERIALS AND METHODS: Imaging data were collected from brain tumor patients (n = 67, average age 48 years) and vascular lesion patients (n = 25, average age 43 years) who received pre-operative fMRI scanning. Both patient groups performed expressive (antonym and/or letter-word generation) and receptive (tumor patients performed text-reading; vascular lesion patients performed text-listening) language tasks. A control group (n = 25, average age 45 years) performed the letter-word generation task. RESULTS: Brain tumor patients showed left-lateralization during the antonym-word generation and text-reading tasks at high threshold values and bilateral activation during the letter-word generation task, irrespective of the threshold values. Vascular lesion patients showed left-lateralization during the antonym and letter-word generation, and text-listening tasks at high threshold values. CONCLUSION: Our results suggest that the type of task and the applied statistical threshold influence LI and that the threshold effects on LI may be task-specific. Thus identifying critical functional regions and computing LIs should be conducted on an individual subject basis, using a continuum of threshold values with different tasks to provide the most accurate information for surgical planning to minimize post-operative language deficits. Elsevier 2014-12-24 /pmc/articles/PMC4310930/ /pubmed/25685705 http://dx.doi.org/10.1016/j.nicl.2014.12.014 Text en © 2014 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Nadkarni, Tanvi N.
Andreoli, Matthew J.
Nair, Veena A.
Yin, Peng
Young, Brittany M.
Kundu, Bornali
Pankratz, Joshua
Radtke, Andrew
Holdsworth, Ryan
Kuo, John S.
Field, Aaron S.
Baskaya, Mustafa K.
Moritz, Chad H.
Meyerand, M. Elizabeth
Prabhakaran, Vivek
Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()
title Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()
title_full Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()
title_fullStr Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()
title_full_unstemmed Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()
title_short Usage of fMRI for pre-surgical planning in brain tumor and vascular lesion patients: Task and statistical threshold effects on language lateralization()()
title_sort usage of fmri for pre-surgical planning in brain tumor and vascular lesion patients: task and statistical threshold effects on language lateralization()()
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310930/
https://www.ncbi.nlm.nih.gov/pubmed/25685705
http://dx.doi.org/10.1016/j.nicl.2014.12.014
work_keys_str_mv AT nadkarnitanvin usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT andreolimatthewj usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT nairveenaa usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT yinpeng usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT youngbrittanym usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT kundubornali usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT pankratzjoshua usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT radtkeandrew usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT holdsworthryan usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT kuojohns usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT fieldaarons usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT baskayamustafak usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT moritzchadh usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT meyerandmelizabeth usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization
AT prabhakaranvivek usageoffmriforpresurgicalplanninginbraintumorandvascularlesionpatientstaskandstatisticalthresholdeffectsonlanguagelateralization