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Pediatric Heart Failure: Current State and Future Possibilities
Heart failure is a complex pathophysiological syndrome that can occur in children from a variety of diseases, including cardiomyopathies, myocarditis, and congenital heart disease. The condition is associated with a high rate of morbidity and mortality and places a significant burden on families of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Cardiology
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310974/ https://www.ncbi.nlm.nih.gov/pubmed/25653697 http://dx.doi.org/10.4070/kcj.2015.45.1.1 |
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author | Rossano, Joseph W. Jang, Gi Young |
author_facet | Rossano, Joseph W. Jang, Gi Young |
author_sort | Rossano, Joseph W. |
collection | PubMed |
description | Heart failure is a complex pathophysiological syndrome that can occur in children from a variety of diseases, including cardiomyopathies, myocarditis, and congenital heart disease. The condition is associated with a high rate of morbidity and mortality and places a significant burden on families of affected children and to society as a whole. Current medical therapy is taken largely from the management of heart failure in adults, though clear survival benefit of these medications are lacking. Ventricular assist devices (VADs) have taken an increasingly important role in the management of advanced heart failure in children. The predominant role of these devices has been as a bridge to heart transplantation, and excellent results are currently achieved for most children with cardiomyopathies. There is an ongoing investigation to improve outcomes in high-risk populations, such as small infants and those with complex congenital heart disease, including patients with functionally univentricular hearts. Additionally, there is an active investigation and interest in expansion of VADs beyond the predominant utilization as a bridge to a heart transplant into ventricular recovery, device explant without a heart transplantation (bridge to recovery), and placement of devices without the expectation of recovery or transplantation (destination therapy). |
format | Online Article Text |
id | pubmed-4310974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-43109742015-02-04 Pediatric Heart Failure: Current State and Future Possibilities Rossano, Joseph W. Jang, Gi Young Korean Circ J Review Article Heart failure is a complex pathophysiological syndrome that can occur in children from a variety of diseases, including cardiomyopathies, myocarditis, and congenital heart disease. The condition is associated with a high rate of morbidity and mortality and places a significant burden on families of affected children and to society as a whole. Current medical therapy is taken largely from the management of heart failure in adults, though clear survival benefit of these medications are lacking. Ventricular assist devices (VADs) have taken an increasingly important role in the management of advanced heart failure in children. The predominant role of these devices has been as a bridge to heart transplantation, and excellent results are currently achieved for most children with cardiomyopathies. There is an ongoing investigation to improve outcomes in high-risk populations, such as small infants and those with complex congenital heart disease, including patients with functionally univentricular hearts. Additionally, there is an active investigation and interest in expansion of VADs beyond the predominant utilization as a bridge to a heart transplant into ventricular recovery, device explant without a heart transplantation (bridge to recovery), and placement of devices without the expectation of recovery or transplantation (destination therapy). The Korean Society of Cardiology 2015-01 2015-01-26 /pmc/articles/PMC4310974/ /pubmed/25653697 http://dx.doi.org/10.4070/kcj.2015.45.1.1 Text en Copyright © 2015 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rossano, Joseph W. Jang, Gi Young Pediatric Heart Failure: Current State and Future Possibilities |
title | Pediatric Heart Failure: Current State and Future Possibilities |
title_full | Pediatric Heart Failure: Current State and Future Possibilities |
title_fullStr | Pediatric Heart Failure: Current State and Future Possibilities |
title_full_unstemmed | Pediatric Heart Failure: Current State and Future Possibilities |
title_short | Pediatric Heart Failure: Current State and Future Possibilities |
title_sort | pediatric heart failure: current state and future possibilities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310974/ https://www.ncbi.nlm.nih.gov/pubmed/25653697 http://dx.doi.org/10.4070/kcj.2015.45.1.1 |
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