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Pediatric Heart Failure: Current State and Future Possibilities

Heart failure is a complex pathophysiological syndrome that can occur in children from a variety of diseases, including cardiomyopathies, myocarditis, and congenital heart disease. The condition is associated with a high rate of morbidity and mortality and places a significant burden on families of...

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Detalles Bibliográficos
Autores principales: Rossano, Joseph W., Jang, Gi Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310974/
https://www.ncbi.nlm.nih.gov/pubmed/25653697
http://dx.doi.org/10.4070/kcj.2015.45.1.1
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author Rossano, Joseph W.
Jang, Gi Young
author_facet Rossano, Joseph W.
Jang, Gi Young
author_sort Rossano, Joseph W.
collection PubMed
description Heart failure is a complex pathophysiological syndrome that can occur in children from a variety of diseases, including cardiomyopathies, myocarditis, and congenital heart disease. The condition is associated with a high rate of morbidity and mortality and places a significant burden on families of affected children and to society as a whole. Current medical therapy is taken largely from the management of heart failure in adults, though clear survival benefit of these medications are lacking. Ventricular assist devices (VADs) have taken an increasingly important role in the management of advanced heart failure in children. The predominant role of these devices has been as a bridge to heart transplantation, and excellent results are currently achieved for most children with cardiomyopathies. There is an ongoing investigation to improve outcomes in high-risk populations, such as small infants and those with complex congenital heart disease, including patients with functionally univentricular hearts. Additionally, there is an active investigation and interest in expansion of VADs beyond the predominant utilization as a bridge to a heart transplant into ventricular recovery, device explant without a heart transplantation (bridge to recovery), and placement of devices without the expectation of recovery or transplantation (destination therapy).
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spelling pubmed-43109742015-02-04 Pediatric Heart Failure: Current State and Future Possibilities Rossano, Joseph W. Jang, Gi Young Korean Circ J Review Article Heart failure is a complex pathophysiological syndrome that can occur in children from a variety of diseases, including cardiomyopathies, myocarditis, and congenital heart disease. The condition is associated with a high rate of morbidity and mortality and places a significant burden on families of affected children and to society as a whole. Current medical therapy is taken largely from the management of heart failure in adults, though clear survival benefit of these medications are lacking. Ventricular assist devices (VADs) have taken an increasingly important role in the management of advanced heart failure in children. The predominant role of these devices has been as a bridge to heart transplantation, and excellent results are currently achieved for most children with cardiomyopathies. There is an ongoing investigation to improve outcomes in high-risk populations, such as small infants and those with complex congenital heart disease, including patients with functionally univentricular hearts. Additionally, there is an active investigation and interest in expansion of VADs beyond the predominant utilization as a bridge to a heart transplant into ventricular recovery, device explant without a heart transplantation (bridge to recovery), and placement of devices without the expectation of recovery or transplantation (destination therapy). The Korean Society of Cardiology 2015-01 2015-01-26 /pmc/articles/PMC4310974/ /pubmed/25653697 http://dx.doi.org/10.4070/kcj.2015.45.1.1 Text en Copyright © 2015 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rossano, Joseph W.
Jang, Gi Young
Pediatric Heart Failure: Current State and Future Possibilities
title Pediatric Heart Failure: Current State and Future Possibilities
title_full Pediatric Heart Failure: Current State and Future Possibilities
title_fullStr Pediatric Heart Failure: Current State and Future Possibilities
title_full_unstemmed Pediatric Heart Failure: Current State and Future Possibilities
title_short Pediatric Heart Failure: Current State and Future Possibilities
title_sort pediatric heart failure: current state and future possibilities
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310974/
https://www.ncbi.nlm.nih.gov/pubmed/25653697
http://dx.doi.org/10.4070/kcj.2015.45.1.1
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