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A non-mitotic role for Aurora kinase A as a direct activator of cell migration upon interaction with PLD, FAK and Src

Timely activation of Aurora kinase A (AURA, also known as AURKA) is vital for centrosome formation and the progression of mitosis. Nonetheless, it is still unclear if and when other cellular functions are activated by AURA. We report here that Src phosphorylates and activates AURA at T288, and AURA...

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Detalles Bibliográficos
Autores principales: Mahankali, Madhu, Henkels, Karen M., Speranza, Francis, Gomez-Cambronero, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311130/
https://www.ncbi.nlm.nih.gov/pubmed/25501815
http://dx.doi.org/10.1242/jcs.157339