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The dynamic conformational landscape of γ-secretase

The structure and function of the γ-secretase proteases are of great interest because of their crucial roles in cellular and disease processes. We established a novel purification protocol for the γ-secretase complex that involves a conformation- and complex-specific nanobody, yielding highly pure a...

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Detalles Bibliográficos
Autores principales:	Elad, Nadav, De Strooper, Bart, Lismont, Sam, Hagen, Wim, Veugelen, Sarah, Arimon, Muriel, Horré, Katrien, Berezovska, Oksana, Sachse, Carsten, Chávez-Gutiérrez, Lucía
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311135/ https://www.ncbi.nlm.nih.gov/pubmed/25501811 http://dx.doi.org/10.1242/jcs.164384

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