Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathies can result in tau mislocalization and dysfuncti...

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Detalles Bibliográficos
Autores principales: Flach, Katharina, Ramminger, Ellen, Hilbrich, Isabel, Arsalan-Werner, Annika, Albrecht, Franziska, Herrmann, Lydia, Goedert, Michel, Arendt, Thomas, Holzer, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311138/
https://www.ncbi.nlm.nih.gov/pubmed/24905733
http://dx.doi.org/10.1016/j.bbadis.2014.05.029

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