Cargando…

H2A.Z: a molecular rheostat for transcriptional control

The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent...

Descripción completa

Detalles Bibliográficos
Autores principales: Subramanian*, Vidya, Fields*, Paul A., Boyer, Laurie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311278/
https://www.ncbi.nlm.nih.gov/pubmed/25705384
http://dx.doi.org/10.12703/P7-01
_version_ 1782354963707461632
author Subramanian*, Vidya
Fields*, Paul A.
Boyer, Laurie A.
author_facet Subramanian*, Vidya
Fields*, Paul A.
Boyer, Laurie A.
author_sort Subramanian*, Vidya
collection PubMed
description The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostat for gene control. We focus on specific examples in metazoans as a model for understanding how H2A.Z integrates information from histone post-translational modifications, other histone variants, and transcription factors (TFs) to regulate proper induction of gene expression programs in response to cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatin states in diverse processes.
format Online
Article
Text
id pubmed-4311278
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Faculty of 1000 Ltd
record_format MEDLINE/PubMed
spelling pubmed-43112782015-02-20 H2A.Z: a molecular rheostat for transcriptional control Subramanian*, Vidya Fields*, Paul A. Boyer, Laurie A. F1000Prime Rep Review Article The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostat for gene control. We focus on specific examples in metazoans as a model for understanding how H2A.Z integrates information from histone post-translational modifications, other histone variants, and transcription factors (TFs) to regulate proper induction of gene expression programs in response to cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatin states in diverse processes. Faculty of 1000 Ltd 2015-01-05 /pmc/articles/PMC4311278/ /pubmed/25705384 http://dx.doi.org/10.12703/P7-01 Text en © 2015 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Subramanian*, Vidya
Fields*, Paul A.
Boyer, Laurie A.
H2A.Z: a molecular rheostat for transcriptional control
title H2A.Z: a molecular rheostat for transcriptional control
title_full H2A.Z: a molecular rheostat for transcriptional control
title_fullStr H2A.Z: a molecular rheostat for transcriptional control
title_full_unstemmed H2A.Z: a molecular rheostat for transcriptional control
title_short H2A.Z: a molecular rheostat for transcriptional control
title_sort h2a.z: a molecular rheostat for transcriptional control
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311278/
https://www.ncbi.nlm.nih.gov/pubmed/25705384
http://dx.doi.org/10.12703/P7-01
work_keys_str_mv AT subramanianvidya h2azamolecularrheostatfortranscriptionalcontrol
AT fieldspaula h2azamolecularrheostatfortranscriptionalcontrol
AT boyerlauriea h2azamolecularrheostatfortranscriptionalcontrol