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H2A.Z: a molecular rheostat for transcriptional control
The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of 1000 Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311278/ https://www.ncbi.nlm.nih.gov/pubmed/25705384 http://dx.doi.org/10.12703/P7-01 |
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author | Subramanian*, Vidya Fields*, Paul A. Boyer, Laurie A. |
author_facet | Subramanian*, Vidya Fields*, Paul A. Boyer, Laurie A. |
author_sort | Subramanian*, Vidya |
collection | PubMed |
description | The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostat for gene control. We focus on specific examples in metazoans as a model for understanding how H2A.Z integrates information from histone post-translational modifications, other histone variants, and transcription factors (TFs) to regulate proper induction of gene expression programs in response to cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatin states in diverse processes. |
format | Online Article Text |
id | pubmed-4311278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43112782015-02-20 H2A.Z: a molecular rheostat for transcriptional control Subramanian*, Vidya Fields*, Paul A. Boyer, Laurie A. F1000Prime Rep Review Article The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNA-mediated processes across eukaryotes and for early development of multicellular organisms. How this variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discuss recent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostat for gene control. We focus on specific examples in metazoans as a model for understanding how H2A.Z integrates information from histone post-translational modifications, other histone variants, and transcription factors (TFs) to regulate proper induction of gene expression programs in response to cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatin states in diverse processes. Faculty of 1000 Ltd 2015-01-05 /pmc/articles/PMC4311278/ /pubmed/25705384 http://dx.doi.org/10.12703/P7-01 Text en © 2015 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode All F1000Prime Reports articles are distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Subramanian*, Vidya Fields*, Paul A. Boyer, Laurie A. H2A.Z: a molecular rheostat for transcriptional control |
title | H2A.Z: a molecular rheostat for transcriptional control |
title_full | H2A.Z: a molecular rheostat for transcriptional control |
title_fullStr | H2A.Z: a molecular rheostat for transcriptional control |
title_full_unstemmed | H2A.Z: a molecular rheostat for transcriptional control |
title_short | H2A.Z: a molecular rheostat for transcriptional control |
title_sort | h2a.z: a molecular rheostat for transcriptional control |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311278/ https://www.ncbi.nlm.nih.gov/pubmed/25705384 http://dx.doi.org/10.12703/P7-01 |
work_keys_str_mv | AT subramanianvidya h2azamolecularrheostatfortranscriptionalcontrol AT fieldspaula h2azamolecularrheostatfortranscriptionalcontrol AT boyerlauriea h2azamolecularrheostatfortranscriptionalcontrol |