Cargando…

Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study

BACKGROUND & OBJECTIVES: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the...

Descripción completa

Detalles Bibliográficos
Autores principales: Khalighi, A.R., Khalighi, M.R., Behdani, R., Jamali, J., Khosravi, A., Kouhestani, Sh., Radmanesh, H., Esmaeelzadeh, S., Khalighi, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311312/
https://www.ncbi.nlm.nih.gov/pubmed/25579140
_version_ 1782354969174736896
author Khalighi, A.R.
Khalighi, M.R.
Behdani, R.
Jamali, J.
Khosravi, A.
Kouhestani, Sh.
Radmanesh, H.
Esmaeelzadeh, S.
Khalighi, N.
author_facet Khalighi, A.R.
Khalighi, M.R.
Behdani, R.
Jamali, J.
Khosravi, A.
Kouhestani, Sh.
Radmanesh, H.
Esmaeelzadeh, S.
Khalighi, N.
author_sort Khalighi, A.R.
collection PubMed
description BACKGROUND & OBJECTIVES: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. METHODS: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. RESULTS: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely (P=0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group (P<0.05). INTERPRETATION & CONCLUSIONS: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome.
format Online
Article
Text
id pubmed-4311312
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-43113122015-02-05 Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study Khalighi, A.R. Khalighi, M.R. Behdani, R. Jamali, J. Khosravi, A. Kouhestani, Sh. Radmanesh, H. Esmaeelzadeh, S. Khalighi, N. Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Small intestinal bacterial overgrowth (SIBO) leads to several gastrointestinal (GI) problems and complications leading to malabsorption. The effectiveness of probiotics in the treatment of SIBO syndrome has not been well studied. This pilot study was aimed to assess the efficacy of a probiotic consisting of lactobacilli in the treatment of SIBO. METHODS: In this study, 30 cases suffering from chronic abdominal pain or diarrhoea and with a positive hydrogen breath test were randomized in a double-blind manner into two groups: probiotic drug user and control group. After an initial 3-week aggressive therapy with broad-spectrum antibiotics, a 15-day maintenance antibiotic therapy with lactol was administered for the study group and the same regimen without lactol for the control group. After six months the HBT result and the GI symptoms were analyzed and compared between the two groups. RESULTS: The result of hydrogen breath test and the clinical symptoms in patients receiving the maintenance regimen with lactol probiotic showed a better response. The hydrogen breath test turned negative in 93.3 per cent of those receiving lactol compared to 66.7 per cent of the controls. In all the cases receiving lactol, the abdominal pain disappeared completely (P=0.002). In addition, other GI problems including flatulence, belching and diarrhoea significantly improved in the study group (P<0.05). INTERPRETATION & CONCLUSIONS: Based on the preliminary data it seems that adding lactol probiotic to the maintenance therapy of small intestinal bacterial overgrowth patients on routine antibiotic therapy will be beneficial in preventing the complications of this syndrome. Medknow Publications & Media Pvt Ltd 2014-11 /pmc/articles/PMC4311312/ /pubmed/25579140 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Khalighi, A.R.
Khalighi, M.R.
Behdani, R.
Jamali, J.
Khosravi, A.
Kouhestani, Sh.
Radmanesh, H.
Esmaeelzadeh, S.
Khalighi, N.
Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
title Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
title_full Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
title_fullStr Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
title_full_unstemmed Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
title_short Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) - A pilot study
title_sort evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (sibo) - a pilot study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311312/
https://www.ncbi.nlm.nih.gov/pubmed/25579140
work_keys_str_mv AT khalighiar evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT khalighimr evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT behdanir evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT jamalij evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT khosravia evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT kouhestanish evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT radmaneshh evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT esmaeelzadehs evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy
AT khalighin evaluatingtheefficacyofprobioticontreatmentinpatientswithsmallintestinalbacterialovergrowthsiboapilotstudy