Two New Steroidal Saponins from Ypsilandra thibetica

ABSTRACT: Two new monosaccharide steroidal saponins, named ypsilandroside S (1) and ypsilandroside T (2), have been isolated from the whole plants of Ypsilandra thibetica. Their structures were elucidated as heloniogenin 3-O-β-D-apiofuranoside (1) and pregna 5,16-dien-3β,12α-diol-20-one-3-O-β-D-apio...

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Detalles Bibliográficos
Autores principales: Si, Yong-Ai, Yan, Huan, Ni, Wei, Liu, Zhen-Hua, Lu, Ting-Xiang, Cheng, Chang-Xiang, Liu, Hai-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311525/
https://www.ncbi.nlm.nih.gov/pubmed/25367351
http://dx.doi.org/10.1007/s13659-014-0043-1
Descripción
Sumario:ABSTRACT: Two new monosaccharide steroidal saponins, named ypsilandroside S (1) and ypsilandroside T (2), have been isolated from the whole plants of Ypsilandra thibetica. Their structures were elucidated as heloniogenin 3-O-β-D-apiofuranoside (1) and pregna 5,16-dien-3β,12α-diol-20-one-3-O-β-D-apiofuranoside (2) by spectroscopic techniques (1D and 2D NMR, MS). Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. GRAPHICAL ABSTRACT: [Image: see text]

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