Cargando…

Multicomponent versus domino reactions: One-pot free-radical synthesis of β-amino-ethers and β-amino-alcohols

Following an optimized multicomponent procedure, an aryl amine, a ketone, and a cyclic ether or an alcohol molecule are assembled in a one-pot synthesis by nucleophilic radical addition of ketyl radicals to ketimines generated in situ. The reaction occurs under mild conditions by mediation of the Ti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rossi, Bianca, Pastori, Nadia, Prosperini, Simona, Punta, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2015
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311587/ https://www.ncbi.nlm.nih.gov/pubmed/25670994 http://dx.doi.org/10.3762/bjoc.11.10

Ejemplares similares

New Advances in Titanium-Mediated Free Radical Reactions
por: Rossi, Bianca, et al.
Publicado: (2012)

Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles
por: Park, Sunhwa, et al.
Publicado: (2017)

Molecular iodine-catalyzed one-pot multicomponent synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles
por: Pires, Camila S, et al.
Publicado: (2018)

Multicomponent Domino Cyclization of Ethyl Trifluoropyruvate with Methyl Ketones and Amino Alcohols as A New Way to γ-Lactam Annulated Oxazacycles
por: Goryaeva, Marina V., et al.
Publicado: (2023)

Development of Stereocontrolled Palladium(II)-Catalyzed Domino Heck/Suzuki β,α-Diarylation Reactions with Chelating Vinyl Ethers and Arylboronic Acids
por: Trejos, Alejandro, et al.
Publicado: (2012)

Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols
por: Saya, Jordy M., et al.
Publicado: (2018)

Kinetics Studies on a Multicomponent Knoevenagel−Michael Domino Reaction by an Automated Flow Reactor
por: Haas, Christian P., et al.
Publicado: (2019)

Versatile synthesis of amino acid functionalized nucleosides via a domino carboxamidation reaction
por: Gheerardijn, Vicky, et al.
Publicado: (2014)

Enantioselective radical C–H amination for the synthesis of β-amino alcohols
por: Nakafuku, Kohki M., et al.
Publicado: (2020)

Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors
por: Bassini, Emanuele, et al.
Publicado: (2020)

Synthesis of functionalised β-keto amides by aminoacylation/domino fragmentation of β-enamino amides
por: Yanev, Pavel, et al.
Publicado: (2018)

Oxa‐Michael Addition to α,β‐Unsaturated Nitriles: An Expedient Route to γ‐Amino Alcohols and Derivatives
por: Guo, Beibei, et al.
Publicado: (2018)

Asymmetric Synthesis of Tetrahydropyridines via an Organocatalytic One-Pot Multicomponent Michael/Aza-Henry/Cyclization Triple Domino Reaction
por: Blümel, Marcus, et al.
Publicado: (2014)

Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds
por: Lipson, Victoria V, et al.
Publicado: (2019)

Synthesis and Antimalarial Evaluation of Cyclicβ-Amino Acid-Containing Dipeptides
por: Sathe, Manisha, et al.
Publicado: (2008)

Pyrrole‐Protected β‐Aminoalkylzinc Reagents for the Enantioselective Synthesis of Amino‐Derivatives
por: Leroux, Marcel, et al.
Publicado: (2020)

Amino‐Supported Palladium Catalyst for Chemo‐ and Stereoselective Domino Reactions
por: Li, Man‐Bo, et al.
Publicado: (2020)

One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles
por: Aboonajmi, Jasem, et al.
Publicado: (2021)

A novel and efficient synthesis of phenanthrene derivatives via palladium/norbornadiene-catalyzed domino one-pot reaction
por: Zhong, Yue, et al.
Publicado: (2019)

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
por: Lucas, Tobias, et al.
Publicado: (2020)

Eugenol β-Amino/β-Alkoxy Alcohols with Selective Anticancer Activity
por: Teixeira, Cláudia, et al.
Publicado: (2022)

β-Amino functionalization of cinnamic Weinreb amides in ionic liquid
por: Wang, Yi-Ning, et al.
Publicado: (2016)

Microwave-Enhanced Sulphated Zirconia and SZ/MCM-41 Catalyzed Regioselective Synthesis of β-Amino Alcohols Under Solvent-Free Conditions
por: Negrón-Silva, Guillermo, et al.
Publicado: (2008)

Dynamics and interactions of ibuprofen in cyclodextrin nanosponges by solid-state NMR spectroscopy
por: Ferro, Monica, et al.
Publicado: (2017)

Mechanochemical enzymatic resolution of N-benzylated-β(3)-amino esters
por: Pérez-Venegas, Mario, et al.
Publicado: (2017)

One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids
por: Cal, Marta, et al.
Publicado: (2012)

Selective deoxygenative alkylation of alcohols via photocatalytic domino radical fragmentations
por: Guo, Hong-Mei, et al.
Publicado: (2021)

Non‐Covalent Interactions in Molecular Systems: Thermodynamic Evaluation of the Hydrogen‐Bond Strength in Amino‐Ethers and Amino‐Alcohols
por: Siewert, Riko, et al.
Publicado: (2022)

Features of the behavior of 4-amino-5-carboxamido-1,2,3-triazole in multicomponent heterocyclizations with carbonyl compounds
por: Gladkov, Eugene S, et al.
Publicado: (2012)

A catalyst-free multicomponent domino sequence for the diastereoselective synthesis of (E)-3-[2-arylcarbonyl-3-(arylamino)allyl]chromen-4-ones
por: Prasanna, Pitchaimani, et al.
Publicado: (2014)

Environmentally friendly domino multicomponent strategy for the synthesis of pyrroloquinolinone hybrid heterocycles
por: Mani, Suresh, et al.
Publicado: (2022)

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity
por: Zhao, Hua, et al.
Publicado: (2023)

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity
por: Bosica, Giovanna, et al.
Publicado: (2020)

Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels
por: Pasc, Andreea, et al.
Publicado: (2010)

Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis
por: Mlostoń, Grzegorz, et al.
Publicado: (2010)

Synthesis, properties, and application of the new nanocatalyst of double layer hydroxides in the one-pot multicomponent synthesis of 2-amino-3-cyanopyridine derivatives
por: Momeni, Sarieh, et al.
Publicado: (2023)

Benchtop NMR for Online Reaction Monitoring of the Biocatalytic Synthesis of Aromatic Amino Alcohols
por: Claaßen, C., et al.
Publicado: (2020)

The unexpected influence of aryl substituents in N-aryl-3-oxobutanamides on the behavior of their multicomponent reactions with 5-amino-3-methylisoxazole and salicylaldehyde
por: Tkachenko, Volodymyr V, et al.
Publicado: (2014)

Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
por: Arumugam, Natarajan, et al.
Publicado: (2018)

Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity
por: Myszka, Henryk, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fm8h1jas0a9l1hb4ai1ij6arbp