Cargando…
To die or not to die? Lessons from lesion mimic mutants
Programmed cell death (PCD) is a ubiquitous genetically regulated process consisting in an activation of finely controlled signaling pathways that lead to cellular suicide. Although some aspects of PCD control appear evolutionary conserved between plants, animals and fungi, the extent of conservatio...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311611/ https://www.ncbi.nlm.nih.gov/pubmed/25688254 http://dx.doi.org/10.3389/fpls.2015.00024 |
_version_ | 1782355025139335168 |
---|---|
author | Bruggeman, Quentin Raynaud, Cécile Benhamed, Moussa Delarue, Marianne |
author_facet | Bruggeman, Quentin Raynaud, Cécile Benhamed, Moussa Delarue, Marianne |
author_sort | Bruggeman, Quentin |
collection | PubMed |
description | Programmed cell death (PCD) is a ubiquitous genetically regulated process consisting in an activation of finely controlled signaling pathways that lead to cellular suicide. Although some aspects of PCD control appear evolutionary conserved between plants, animals and fungi, the extent of conservation remains controversial. Over the last decades, identification and characterization of several lesion mimic mutants (LMM) has been a powerful tool in the quest to unravel PCD pathways in plants. Thanks to progress in molecular genetics, mutations causing the phenotype of a large number of LMM and their related suppressors were mapped, and the identification of the mutated genes shed light on major pathways in the onset of plant PCD such as (i) the involvements of chloroplasts and light energy, (ii) the roles of sphingolipids and fatty acids, (iii) a signal perception at the plasma membrane that requires efficient membrane trafficking, (iv) secondary messengers such as ion fluxes and ROS and (v) the control of gene expression as the last integrator of the signaling pathways. |
format | Online Article Text |
id | pubmed-4311611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43116112015-02-16 To die or not to die? Lessons from lesion mimic mutants Bruggeman, Quentin Raynaud, Cécile Benhamed, Moussa Delarue, Marianne Front Plant Sci Plant Science Programmed cell death (PCD) is a ubiquitous genetically regulated process consisting in an activation of finely controlled signaling pathways that lead to cellular suicide. Although some aspects of PCD control appear evolutionary conserved between plants, animals and fungi, the extent of conservation remains controversial. Over the last decades, identification and characterization of several lesion mimic mutants (LMM) has been a powerful tool in the quest to unravel PCD pathways in plants. Thanks to progress in molecular genetics, mutations causing the phenotype of a large number of LMM and their related suppressors were mapped, and the identification of the mutated genes shed light on major pathways in the onset of plant PCD such as (i) the involvements of chloroplasts and light energy, (ii) the roles of sphingolipids and fatty acids, (iii) a signal perception at the plasma membrane that requires efficient membrane trafficking, (iv) secondary messengers such as ion fluxes and ROS and (v) the control of gene expression as the last integrator of the signaling pathways. Frontiers Media S.A. 2015-01-30 /pmc/articles/PMC4311611/ /pubmed/25688254 http://dx.doi.org/10.3389/fpls.2015.00024 Text en Copyright © 2015 Bruggeman, Raynaud, Benhamed and Delarue. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science Bruggeman, Quentin Raynaud, Cécile Benhamed, Moussa Delarue, Marianne To die or not to die? Lessons from lesion mimic mutants |
title | To die or not to die? Lessons from lesion mimic mutants |
title_full | To die or not to die? Lessons from lesion mimic mutants |
title_fullStr | To die or not to die? Lessons from lesion mimic mutants |
title_full_unstemmed | To die or not to die? Lessons from lesion mimic mutants |
title_short | To die or not to die? Lessons from lesion mimic mutants |
title_sort | to die or not to die? lessons from lesion mimic mutants |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311611/ https://www.ncbi.nlm.nih.gov/pubmed/25688254 http://dx.doi.org/10.3389/fpls.2015.00024 |
work_keys_str_mv | AT bruggemanquentin todieornottodielessonsfromlesionmimicmutants AT raynaudcecile todieornottodielessonsfromlesionmimicmutants AT benhamedmoussa todieornottodielessonsfromlesionmimicmutants AT delaruemarianne todieornottodielessonsfromlesionmimicmutants |