Cargando…

Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project

The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in th...

Descripción completa

Detalles Bibliográficos
Autores principales: Laston, Sandra L., Voruganti, V. Saroja, Haack, Karin, Shah, Vallabh O., Bobelu, Arlene, Bobelu, Jeanette, Ghahate, Donica, Harford, Antonia M., Paine, Susan S., Tentori, Francesca, Cole, Shelley A., MacCluer, Jean W., Comuzzie, Anthony G., Zager, Philip G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311707/
https://www.ncbi.nlm.nih.gov/pubmed/25688259
http://dx.doi.org/10.3389/fgene.2015.00006
_version_ 1782355044619780096
author Laston, Sandra L.
Voruganti, V. Saroja
Haack, Karin
Shah, Vallabh O.
Bobelu, Arlene
Bobelu, Jeanette
Ghahate, Donica
Harford, Antonia M.
Paine, Susan S.
Tentori, Francesca
Cole, Shelley A.
MacCluer, Jean W.
Comuzzie, Anthony G.
Zager, Philip G.
author_facet Laston, Sandra L.
Voruganti, V. Saroja
Haack, Karin
Shah, Vallabh O.
Bobelu, Arlene
Bobelu, Jeanette
Ghahate, Donica
Harford, Antonia M.
Paine, Susan S.
Tentori, Francesca
Cole, Shelley A.
MacCluer, Jean W.
Comuzzie, Anthony G.
Zager, Philip G.
author_sort Laston, Sandra L.
collection PubMed
description The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (p < 1.58 × 10(-7)) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10(-6)) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions.
format Online
Article
Text
id pubmed-4311707
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-43117072015-02-16 Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project Laston, Sandra L. Voruganti, V. Saroja Haack, Karin Shah, Vallabh O. Bobelu, Arlene Bobelu, Jeanette Ghahate, Donica Harford, Antonia M. Paine, Susan S. Tentori, Francesca Cole, Shelley A. MacCluer, Jean W. Comuzzie, Anthony G. Zager, Philip G. Front Genet Genetics The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and hypertension were 24%, 30%, 17% and 34%, respectively. We found a significant (p < 1.58 × 10(-7)) association for a SNP in a novel gene for serum creatinine (PTPLAD2). We replicated significant associations for genes with serum uric acid (SLC2A9), triglyceride levels (APOA1, BUD13, ZNF259), and total cholesterol (PVRL2). We found novel suggestive associations (p < 1.58 × 10(-6)) for SNPs in genes with systolic (OLFML2B), and diastolic blood pressure (NFIA). We identified a series of genes associated with CKD and related cardiometabolic phenotypes among Zuni Indians, a population with a high prevalence of kidney disease. Illuminating genetic variations that modulate the risk for these disorders may ultimately provide a basis for novel preventive strategies and therapeutic interventions. Frontiers Media S.A. 2015-01-30 /pmc/articles/PMC4311707/ /pubmed/25688259 http://dx.doi.org/10.3389/fgene.2015.00006 Text en Copyright © 2015 Laston, Voruganti, Haack, Shah, Bobelu, Bobelu, Ghahate, Harford, Paine, Tentori, Cole, MacCluer, Comuzzie and Zager. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Laston, Sandra L.
Voruganti, V. Saroja
Haack, Karin
Shah, Vallabh O.
Bobelu, Arlene
Bobelu, Jeanette
Ghahate, Donica
Harford, Antonia M.
Paine, Susan S.
Tentori, Francesca
Cole, Shelley A.
MacCluer, Jean W.
Comuzzie, Anthony G.
Zager, Philip G.
Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
title Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
title_full Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
title_fullStr Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
title_full_unstemmed Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
title_short Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project
title_sort genetics of kidney disease and related cardiometabolic phenotypes in zuni indians: the zuni kidney project
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311707/
https://www.ncbi.nlm.nih.gov/pubmed/25688259
http://dx.doi.org/10.3389/fgene.2015.00006
work_keys_str_mv AT lastonsandral geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT vorugantivsaroja geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT haackkarin geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT shahvallabho geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT bobeluarlene geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT bobelujeanette geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT ghahatedonica geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT harfordantoniam geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT painesusans geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT tentorifrancesca geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT coleshelleya geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT maccluerjeanw geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT comuzzieanthonyg geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject
AT zagerphilipg geneticsofkidneydiseaseandrelatedcardiometabolicphenotypesinzuniindiansthezunikidneyproject