Cargando…

Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging

Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unkno...

Descripción completa

Detalles Bibliográficos
Autores principales: Marzetti, Emanuele, Privitera, Giuseppe, Simili, Vincenzo, Wohlgemuth, Stephanie E., Aulisa, Lorenzo, Pahor, Marco, Leeuwenburgh, Christiaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311890/
https://www.ncbi.nlm.nih.gov/pubmed/20191247
http://dx.doi.org/10.1100/tsw.2010.27
_version_ 1782355056236953600
author Marzetti, Emanuele
Privitera, Giuseppe
Simili, Vincenzo
Wohlgemuth, Stephanie E.
Aulisa, Lorenzo
Pahor, Marco
Leeuwenburgh, Christiaan
author_facet Marzetti, Emanuele
Privitera, Giuseppe
Simili, Vincenzo
Wohlgemuth, Stephanie E.
Aulisa, Lorenzo
Pahor, Marco
Leeuwenburgh, Christiaan
author_sort Marzetti, Emanuele
collection PubMed
description Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a possible contributor to the pathogenesis of sarcopenia. Studies in animal models have shown that the severity of skeletal muscle apoptosis increases over the course of aging and correlates with the degree of muscle mass and strength decline. Several apoptotic pathways are operative in aged muscles, with the mitochondria- and TNF-α-mediated pathways likely being the most relevant to sarcopenia. However, despite the growing number of studies on the subject, a definite mechanistic link between myocyte apoptosis and age-related muscle atrophy has not yet been established. Furthermore, the evidence on the role played by apoptosis in human sarcopenia is still sparse. Clearly, further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age. This knowledge will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia.
format Online
Article
Text
id pubmed-4311890
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher TheScientificWorldJOURNAL
record_format MEDLINE/PubMed
spelling pubmed-43118902015-01-30 Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging Marzetti, Emanuele Privitera, Giuseppe Simili, Vincenzo Wohlgemuth, Stephanie E. Aulisa, Lorenzo Pahor, Marco Leeuwenburgh, Christiaan ScientificWorldJournal Mini-Review Article Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a possible contributor to the pathogenesis of sarcopenia. Studies in animal models have shown that the severity of skeletal muscle apoptosis increases over the course of aging and correlates with the degree of muscle mass and strength decline. Several apoptotic pathways are operative in aged muscles, with the mitochondria- and TNF-α-mediated pathways likely being the most relevant to sarcopenia. However, despite the growing number of studies on the subject, a definite mechanistic link between myocyte apoptosis and age-related muscle atrophy has not yet been established. Furthermore, the evidence on the role played by apoptosis in human sarcopenia is still sparse. Clearly, further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age. This knowledge will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia. TheScientificWorldJOURNAL 2010-02-19 /pmc/articles/PMC4311890/ /pubmed/20191247 http://dx.doi.org/10.1100/tsw.2010.27 Text en Copyright © 2010 Emanuele Marzetti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review Article
Marzetti, Emanuele
Privitera, Giuseppe
Simili, Vincenzo
Wohlgemuth, Stephanie E.
Aulisa, Lorenzo
Pahor, Marco
Leeuwenburgh, Christiaan
Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
title Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
title_full Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
title_fullStr Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
title_full_unstemmed Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
title_short Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
title_sort multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging
topic Mini-Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311890/
https://www.ncbi.nlm.nih.gov/pubmed/20191247
http://dx.doi.org/10.1100/tsw.2010.27
work_keys_str_mv AT marzettiemanuele multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging
AT priviteragiuseppe multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging
AT similivincenzo multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging
AT wohlgemuthstephaniee multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging
AT aulisalorenzo multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging
AT pahormarco multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging
AT leeuwenburghchristiaan multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging