Cargando…
Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unkno...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
TheScientificWorldJOURNAL
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311890/ https://www.ncbi.nlm.nih.gov/pubmed/20191247 http://dx.doi.org/10.1100/tsw.2010.27 |
_version_ | 1782355056236953600 |
---|---|
author | Marzetti, Emanuele Privitera, Giuseppe Simili, Vincenzo Wohlgemuth, Stephanie E. Aulisa, Lorenzo Pahor, Marco Leeuwenburgh, Christiaan |
author_facet | Marzetti, Emanuele Privitera, Giuseppe Simili, Vincenzo Wohlgemuth, Stephanie E. Aulisa, Lorenzo Pahor, Marco Leeuwenburgh, Christiaan |
author_sort | Marzetti, Emanuele |
collection | PubMed |
description | Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a possible contributor to the pathogenesis of sarcopenia. Studies in animal models have shown that the severity of skeletal muscle apoptosis increases over the course of aging and correlates with the degree of muscle mass and strength decline. Several apoptotic pathways are operative in aged muscles, with the mitochondria- and TNF-α-mediated pathways likely being the most relevant to sarcopenia. However, despite the growing number of studies on the subject, a definite mechanistic link between myocyte apoptosis and age-related muscle atrophy has not yet been established. Furthermore, the evidence on the role played by apoptosis in human sarcopenia is still sparse. Clearly, further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age. This knowledge will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia. |
format | Online Article Text |
id | pubmed-4311890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | TheScientificWorldJOURNAL |
record_format | MEDLINE/PubMed |
spelling | pubmed-43118902015-01-30 Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging Marzetti, Emanuele Privitera, Giuseppe Simili, Vincenzo Wohlgemuth, Stephanie E. Aulisa, Lorenzo Pahor, Marco Leeuwenburgh, Christiaan ScientificWorldJournal Mini-Review Article Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a possible contributor to the pathogenesis of sarcopenia. Studies in animal models have shown that the severity of skeletal muscle apoptosis increases over the course of aging and correlates with the degree of muscle mass and strength decline. Several apoptotic pathways are operative in aged muscles, with the mitochondria- and TNF-α-mediated pathways likely being the most relevant to sarcopenia. However, despite the growing number of studies on the subject, a definite mechanistic link between myocyte apoptosis and age-related muscle atrophy has not yet been established. Furthermore, the evidence on the role played by apoptosis in human sarcopenia is still sparse. Clearly, further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age. This knowledge will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia. TheScientificWorldJOURNAL 2010-02-19 /pmc/articles/PMC4311890/ /pubmed/20191247 http://dx.doi.org/10.1100/tsw.2010.27 Text en Copyright © 2010 Emanuele Marzetti et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Mini-Review Article Marzetti, Emanuele Privitera, Giuseppe Simili, Vincenzo Wohlgemuth, Stephanie E. Aulisa, Lorenzo Pahor, Marco Leeuwenburgh, Christiaan Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
title | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
title_full | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
title_fullStr | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
title_full_unstemmed | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
title_short | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
title_sort | multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging |
topic | Mini-Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311890/ https://www.ncbi.nlm.nih.gov/pubmed/20191247 http://dx.doi.org/10.1100/tsw.2010.27 |
work_keys_str_mv | AT marzettiemanuele multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging AT priviteragiuseppe multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging AT similivincenzo multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging AT wohlgemuthstephaniee multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging AT aulisalorenzo multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging AT pahormarco multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging AT leeuwenburghchristiaan multiplepathwaystothesameendmechanismsofmyonuclearapoptosisinsarcopeniaofaging |