Targeted images of KB cells using folate-conjugated gold nanoparticles

Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membra...

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Detalles Bibliográficos
Autores principales: Rathinaraj, Pierson, Lee, Kyubae, Park, Soo-Young, Kang, Inn-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311903/
https://www.ncbi.nlm.nih.gov/pubmed/25852305
http://dx.doi.org/10.1186/s11671-014-0725-y
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author Rathinaraj, Pierson
Lee, Kyubae
Park, Soo-Young
Kang, Inn-Kyu
author_facet Rathinaraj, Pierson
Lee, Kyubae
Park, Soo-Young
Kang, Inn-Kyu
author_sort Rathinaraj, Pierson
collection PubMed
description Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.
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spelling pubmed-43119032015-04-07 Targeted images of KB cells using folate-conjugated gold nanoparticles Rathinaraj, Pierson Lee, Kyubae Park, Soo-Young Kang, Inn-Kyu Nanoscale Res Lett Nano Express Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied. Springer US 2015-01-21 /pmc/articles/PMC4311903/ /pubmed/25852305 http://dx.doi.org/10.1186/s11671-014-0725-y Text en © Pierson et al.; licensee Springer. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Nano Express
Rathinaraj, Pierson
Lee, Kyubae
Park, Soo-Young
Kang, Inn-Kyu
Targeted images of KB cells using folate-conjugated gold nanoparticles
title Targeted images of KB cells using folate-conjugated gold nanoparticles
title_full Targeted images of KB cells using folate-conjugated gold nanoparticles
title_fullStr Targeted images of KB cells using folate-conjugated gold nanoparticles
title_full_unstemmed Targeted images of KB cells using folate-conjugated gold nanoparticles
title_short Targeted images of KB cells using folate-conjugated gold nanoparticles
title_sort targeted images of kb cells using folate-conjugated gold nanoparticles
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311903/
https://www.ncbi.nlm.nih.gov/pubmed/25852305
http://dx.doi.org/10.1186/s11671-014-0725-y
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AT kanginnkyu targetedimagesofkbcellsusingfolateconjugatedgoldnanoparticles

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