Modulation of Cytochrome P450 2A5 Activity by Lipopolysaccharide: Low-Dose Effects and Non-Monotonic Dose-Response Relationship

Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and nuclear factor (erythroid 2-related factor) 2 (Nrf2) transcription factor activation have been hypoth...

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Detalles Bibliográficos
Autores principales: De-Oliveira, Ana C. A. X., Poça, Kátia S., Totino, Paulo R. R., Paumgartten, Francisco J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311977/
https://www.ncbi.nlm.nih.gov/pubmed/25635819
http://dx.doi.org/10.1371/journal.pone.0117842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311977/
https://www.ncbi.nlm.nih.gov/pubmed/25635819
http://dx.doi.org/10.1371/journal.pone.0117842

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