SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation

Senescent cells develop a pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). As many SASP components affect surrounding cells and alter their microenvironment, SASP may be a key phenomenon in linking cellular senesence with individual aging and age-related disease...

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Detalles Bibliográficos
Autores principales: Hayakawa, Tomohisa, Iwai, Mika, Aoki, Satoshi, Takimoto, Koichi, Maruyama, Mitsuo, Maruyama, Wakako, Motoyama, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312089/
https://www.ncbi.nlm.nih.gov/pubmed/25635860
http://dx.doi.org/10.1371/journal.pone.0116480

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