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The Mitotic Checkpoint Complex binds a second CDC20 to inhibit active APC/C

The Spindle Assembly Checkpoint (SAC) maintains genomic stability by delaying chromosome segregation until the last chromosome has attached to the mitotic spindle. The SAC prevents the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase from recognising Cyclin B and securin by catalysing t...

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Detalles Bibliográficos
Autores principales:	Izawa, Daisuke, Pines, Jonathon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312099/ https://www.ncbi.nlm.nih.gov/pubmed/25383541 http://dx.doi.org/10.1038/nature13911

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