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Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas

BACKGROUND: Activated PI3K-AKT pathway may contribute to decrease sensitivity to inhibitors of key pathogenetic effectors (mutated BRAF, active NRAS or MEK) in melanoma. Functional alterations are deeply involved in PI3K-AKT activation, with a minimal role reported for mutations in PIK3CA, the catal...

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Detalles Bibliográficos
Autores principales:	Manca, Antonella, Lissia, Amelia, Capone, Mariaelena, Ascierto, Paolo A, Botti, Gerardo, Caracò, Corrado, Stanganelli, Ignazio, Colombino, Maria, Sini, MariaCristina, Cossu, Antonio, Palmieri, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312444/ https://www.ncbi.nlm.nih.gov/pubmed/25627962 http://dx.doi.org/10.1186/s12967-015-0401-8

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