The Combined Inhibitory Effect of the Adenosine A(1) and Cannabinoid CB(1) Receptors on cAMP Accumulation in the Hippocampus Is Additive and Independent of A(1) Receptor Desensitization

Adenosine A(1) and cannabinoid CB(1) receptors are highly expressed in hippocampus where they trigger similar transduction pathways. We investigated how the combined acute activation of A(1) and CB(1) receptors modulates cAMP accumulation in rat hippocampal slices. The CB(1) agonist WIN55212-2 (0.3–...

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Detalles Bibliográficos
Autores principales: Serpa, André, Correia, Sara, Ribeiro, Joaquim A., Sebastião, Ana M., Cascalheira, José F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312621/
https://www.ncbi.nlm.nih.gov/pubmed/25667928
http://dx.doi.org/10.1155/2015/872684

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