Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum

Chromatographic separation of a methanol extract prepared from the whole plant of Dendrobium brymerianum led to the isolation of eight phenolic compounds. Among the isolated compounds (1–8), moscatilin (1), gigantol (3), lusianthridin (4), and dendroflorin (6) showed appreciable cytotoxicity against...

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Autores principales: Klongkumnuankarn, Pornprom, Busaranon, Kesarin, Chanvorachote, Pithi, Sritularak, Boonchoo, Jongbunprasert, Vichien, Likhitwitayawuid, Kittisak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312652/
https://www.ncbi.nlm.nih.gov/pubmed/25685168
http://dx.doi.org/10.1155/2015/350410
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author Klongkumnuankarn, Pornprom
Busaranon, Kesarin
Chanvorachote, Pithi
Sritularak, Boonchoo
Jongbunprasert, Vichien
Likhitwitayawuid, Kittisak
author_facet Klongkumnuankarn, Pornprom
Busaranon, Kesarin
Chanvorachote, Pithi
Sritularak, Boonchoo
Jongbunprasert, Vichien
Likhitwitayawuid, Kittisak
author_sort Klongkumnuankarn, Pornprom
collection PubMed
description Chromatographic separation of a methanol extract prepared from the whole plant of Dendrobium brymerianum led to the isolation of eight phenolic compounds. Among the isolated compounds (1–8), moscatilin (1), gigantol (3), lusianthridin (4), and dendroflorin (6) showed appreciable cytotoxicity against human lung cancer cell lines with IC(50) values of 196.7, 23.4, 65.0, and 125.8 μg/mL, respectively, and exhibited antimigratory property at nontoxic concentrations. This study is the first report on the biological activities of this plant.
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spelling pubmed-43126522015-02-15 Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum Klongkumnuankarn, Pornprom Busaranon, Kesarin Chanvorachote, Pithi Sritularak, Boonchoo Jongbunprasert, Vichien Likhitwitayawuid, Kittisak Evid Based Complement Alternat Med Research Article Chromatographic separation of a methanol extract prepared from the whole plant of Dendrobium brymerianum led to the isolation of eight phenolic compounds. Among the isolated compounds (1–8), moscatilin (1), gigantol (3), lusianthridin (4), and dendroflorin (6) showed appreciable cytotoxicity against human lung cancer cell lines with IC(50) values of 196.7, 23.4, 65.0, and 125.8 μg/mL, respectively, and exhibited antimigratory property at nontoxic concentrations. This study is the first report on the biological activities of this plant. Hindawi Publishing Corporation 2015 2015-01-15 /pmc/articles/PMC4312652/ /pubmed/25685168 http://dx.doi.org/10.1155/2015/350410 Text en Copyright © 2015 Pornprom Klongkumnuankarn et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Klongkumnuankarn, Pornprom
Busaranon, Kesarin
Chanvorachote, Pithi
Sritularak, Boonchoo
Jongbunprasert, Vichien
Likhitwitayawuid, Kittisak
Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
title Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
title_full Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
title_fullStr Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
title_full_unstemmed Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
title_short Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum
title_sort cytotoxic and antimigratory activities of phenolic compounds from dendrobium brymerianum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312652/
https://www.ncbi.nlm.nih.gov/pubmed/25685168
http://dx.doi.org/10.1155/2015/350410
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