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Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas
AIM: Strain elastography is a method for recording tissue hardness. Strain in different areas may be compared using strain ratio (SR). The aims of this study were to validate a previously proposed SR cut-off value of 1.25 for differentiating adenocarcinomas from adenomas and to compare the performan...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312907/ https://www.ncbi.nlm.nih.gov/pubmed/25407010 http://dx.doi.org/10.1111/codi.12845 |
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author | Waage, J E R Leh, S Røsler, C Pfeffer, F Bach, S P Havre, R F Haldorsen, I S Ødegaard, S Baatrup, G |
author_facet | Waage, J E R Leh, S Røsler, C Pfeffer, F Bach, S P Havre, R F Haldorsen, I S Ødegaard, S Baatrup, G |
author_sort | Waage, J E R |
collection | PubMed |
description | AIM: Strain elastography is a method for recording tissue hardness. Strain in different areas may be compared using strain ratio (SR). The aims of this study were to validate a previously proposed SR cut-off value of 1.25 for differentiating adenocarcinomas from adenomas and to compare the performance of endorectal ultrasonography (ERUS), strain elastography and MRI in the same patients. METHOD: A prospective evaluation of 120 consecutive patients with rectal neoplasia, using a predetermined elastography strain ratio cut-off value, was performed to differentiate adenomas from adenocarcinomas. ERUS and MRI were performed according to standard routine at Haukeland University Hospital, defining T0 as adenomas and T1–T4 as adenocarcinomas. Subsequent histopathology was used as the reference standard. RESULTS: Histopathological evaluation revealed 21 adenomas and 99 adenocarcinomas. Sensitivity, specificity and accuracy (with 95% CI) were as follows: ERUS: 0.96 (0.90–0.99), 0.62 (0.40–0.80) and 0.90 (0.83–0.94); elastography SR: 0.96 (0.90–0.99), 0.86 (0.66–0.96) and 0.94 (0.88–0.97); and MRI: 0.99 (0.94–1.00), 0.07 (0.00–0.31) and 0.87 (0.80–0.93). CONCLUSION: This study confirms that the elastography SR assessment accurately differentiates sessile adenomas from adenocarcinomas. SR assessment has a superior ability to differentiate adenomas and adenocarcinomas when compared with ERUS and MRI. MRI examination seems unable to recognize adenomas and should be interpreted with care when early-stage rectal neoplasia is suspected. |
format | Online Article Text |
id | pubmed-4312907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43129072015-02-10 Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas Waage, J E R Leh, S Røsler, C Pfeffer, F Bach, S P Havre, R F Haldorsen, I S Ødegaard, S Baatrup, G Colorectal Dis Original Articles AIM: Strain elastography is a method for recording tissue hardness. Strain in different areas may be compared using strain ratio (SR). The aims of this study were to validate a previously proposed SR cut-off value of 1.25 for differentiating adenocarcinomas from adenomas and to compare the performance of endorectal ultrasonography (ERUS), strain elastography and MRI in the same patients. METHOD: A prospective evaluation of 120 consecutive patients with rectal neoplasia, using a predetermined elastography strain ratio cut-off value, was performed to differentiate adenomas from adenocarcinomas. ERUS and MRI were performed according to standard routine at Haukeland University Hospital, defining T0 as adenomas and T1–T4 as adenocarcinomas. Subsequent histopathology was used as the reference standard. RESULTS: Histopathological evaluation revealed 21 adenomas and 99 adenocarcinomas. Sensitivity, specificity and accuracy (with 95% CI) were as follows: ERUS: 0.96 (0.90–0.99), 0.62 (0.40–0.80) and 0.90 (0.83–0.94); elastography SR: 0.96 (0.90–0.99), 0.86 (0.66–0.96) and 0.94 (0.88–0.97); and MRI: 0.99 (0.94–1.00), 0.07 (0.00–0.31) and 0.87 (0.80–0.93). CONCLUSION: This study confirms that the elastography SR assessment accurately differentiates sessile adenomas from adenocarcinomas. SR assessment has a superior ability to differentiate adenomas and adenocarcinomas when compared with ERUS and MRI. MRI examination seems unable to recognize adenomas and should be interpreted with care when early-stage rectal neoplasia is suspected. BlackWell Publishing Ltd 2015-02 2015-01-21 /pmc/articles/PMC4312907/ /pubmed/25407010 http://dx.doi.org/10.1111/codi.12845 Text en © 2014 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Waage, J E R Leh, S Røsler, C Pfeffer, F Bach, S P Havre, R F Haldorsen, I S Ødegaard, S Baatrup, G Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas |
title | Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas |
title_full | Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas |
title_fullStr | Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas |
title_full_unstemmed | Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas |
title_short | Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas |
title_sort | endorectal ultrasonography, strain elastography and mri differentiation of rectal adenomas and adenocarcinomas |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312907/ https://www.ncbi.nlm.nih.gov/pubmed/25407010 http://dx.doi.org/10.1111/codi.12845 |
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