Accelerating Genome Editing in CHO Cells Using CRISPR Cas9 and CRISPy, a Web-Based Target Finding Tool

Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry as a host for the production of complex pharmaceutical proteins. Thus genome engineering of CHO cells for improved product quality and yield is of great interest. Here, we demonstrate for the first time the efficacy...

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Detalles Bibliográficos
Autores principales: Ronda, Carlotta, Pedersen, Lasse Ebdrup, Hansen, Henning Gram, Kallehauge, Thomas Beuchert, Betenbaugh, Michael J, Nielsen, Alex Toftgaard, Kildegaard, Helene Faustrup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312910/
https://www.ncbi.nlm.nih.gov/pubmed/24827782
http://dx.doi.org/10.1002/bit.25233

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